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Mecamylamine, a secondary amine, readily penetrates into the brain and thus may produce central nervous system effects. Tremor, choreiform movements, mental aberrations, and convulsions may occur rarely. These have occurred most often when large doses of INVERSINE (mecamylamine) were used, especially in patients with cerebral or renal insufficiency.
When ganglion blockers or other potent anti hypertensive drugs are discontinued suddenly, hypertensive levels return. In patients with malignant hypertension and others, this may occur abruptly and may cause fatal cerebral vascular accidents or acute congestive heart failure. When INVERSINE (mecamylamine) is withdrawn, this should be done gradually and other anti hypertensive therapy usually must be substituted. On the other hand, the effects of INVERSINE (mecamylamine) sometimes may last from hours to days after therapy is discontinued.
The patient's condition should be evaluated carefully, particularly as to renal and cardiovascular function. When renal, cerebral, or coronary blood flow is deficient, any additional impairment, which might result from added hypotension, must be avoided. The use of INVERSINE (mecamylamine) in patients with marked cerebral and coronary arteriosclerosis or after a recent cerebral accident requires caution.
The action of INVERSINE (mecamylamine) may be potentiated by . excessive heat, fever, infection, hemorrhage, pregnancy, anesthesia, surgery, vigorous exercise, other anti hypertensive drugs, alcohol, and salt depletion as a result of diminished intake or increased excretion due to diarrhea, vomiting, excessive sweating, or diuretics.
During therapy with INVERSINE (mecamylamine) , sodium intake should not be restricted but, if necessary, the dosage of the ganglion blocker must be adjusted.
Frequent loose bowel movements with abdominal distention and decreased borborygmi may be the first signs of paralytic ileus. If these are present, INVERSINE (mecamylamine) should be discontinued immediately and remedial steps taken.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term studies in animals have not been performed to evaluate the effects upon fertility, mutagenic or carcinogenic potential of INVERSINE (mecamylamine) .
Pregnancy Category C. Animal reproduction studies have not been conducted with INVERSINE (mecamylamine) . It is not known whether INVERSINE (mecamylamine) can cause fetal harm when given to a pregnant woman or can affect reproductive capacity. INVERSINE (mecamylamine) should be given to a pregnant woman only if clearly needed.
Because of the potential for serious adverse reactions in nursing infants from INVERSINE (mecamylamine) , a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Safety and effectiveness in pediatric patients have not been established.
Last reviewed on RxList: 12/2/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Inversine Information
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