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Inversine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Inversine (mecamylamine HCl) is an antihypertensive medication used to treat moderate to severe hypertension (high blood pressure). The brand name of this medication is discontinued, but generic versions may be available. Common side effects include nausea, vomiting, constipation, dry mouth, decreased appetite, dizziness and fainting, drowsiness or weakness, dilated (large) pupils and blurred vision, or difficulty urinating.
Therapy with Inversine is usually started with one 2.5 mg twice a day. The average total daily dosage of Inversine is 25 mg, usually in three divided doses. Inversine may interact with antibiotics, sulfa drugs, other drugs used to lower high blood pressure, drugs used to treat other heart conditions, or anesthesia. Tell your doctor all medications and supplements you use. It is unknown if Inversine will harm a fetus. Do not take this medication without first talking to your doctor if you are pregnant. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Inversine (mecamylamine HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Inversine in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects, stop taking mecamylamine and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or
- abdominal pain, abdominal distention, or diarrhea.
Other, less serious side effects may be more likely to occur. Continue to take mecamylamine and talk to your doctor if you experience
- nausea, vomiting, or constipation;
- dry mouth;
- decreased appetite;
- dizziness and fainting;
- drowsiness or weakness;
- dilated (large) pupils and blurred vision; or
- difficulty urinating.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Inversine (Mecamylamine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Inversine Overview - Patient Information: Side Effects
Hot weather, exercise, or alcohol may increase dizziness and lightheadedness. Fever, vomiting, diarrhea, bleeding, loss of salt, or heavy sweating may also increase dizziness. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, difficulty urinating, shaking (tremor), uncontrolled movements of the face/hands/arms/legs, numb/tingling skin.
If you develop frequent diarrhea with severe stomach/abdominal discomfort and/or bloating while taking this medication, get medical help right away. This may be a sign of a very serious bowel disease (paralytic ileus).
Get medical help right away if you have any very serious side effects, including: mental/mood changes (such as anxiety, confusion, depression), seizures.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Inversine (Mecamylamine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Inversine FDA Prescribing Information: Side Effects
The following adverse reactions have been reported and within each category are listed in order of decreasing severity.
Respiratory:Interstitial pulmonary edema and fibrosis.
Special Senses: Blurred vision, dilated pupils.
Miscellaneous: Weakness, fatigue, sedation.
Read the entire FDA prescribing information for Inversine (Mecamylamine)
Additional Inversine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.