DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: certain antiarrhythmics (such as propafenone), trazodone, certain benzodiazepines (midazolam, triazolam), ergot alkaloids (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine), garlic supplements, ranolazine, rifamycins (such as rifampin, rifapentine), certain "statin" cholesterol drugs (atorvastatin, simvastatin, lovastatin), other HIV medications (such as darunavir, tipranavir), St. John's wort.

Many drugs besides saquinavir may affect the heart rhythm (QT prolongation), including quinidine, pimozide, cisapride, amiodarone, flecainide, salmeterol, among others.

Other medications can affect the removal of saquinavir from your body, which may affect how saquinavir works. Examples include other HIV drugs (such as indinavir, nelfinavir), among others.

Saquinavir can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include drugs to treat erectile dysfunction/pulmonary hypertension (such as sildenafil, vardenafil, tadalafil), among others.

This medication may decrease the effectiveness of hormonal birth control products (such as pills, patch, ring). This effect can result in pregnancy. However, to reduce the risk of spreading HIV to others, always use barrier protections during all sexual activity. (See also Notes section.)

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: To reduce the risk of spreading HIV to others, always use effective barrier protections (such as latex or polyurethane condoms, dental dams) during all sexual activity. Consult your doctor or pharmacist for more details.

Do not share this medication with others.

Laboratory and/or medical tests (such as viral load, triglycerides/ cholesterol, EKG, blood sugar, T-cell counts) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Keep all medical and laboratory appointments.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

Information last revised April 2012. Copyright(c) 2012 First Databank, Inc.