"The U.S. Food and Drug Administration today announced that new safety information has been added to the label for the HIV antiviral drug Invirase (saquinavir), describing potentially life-threatening side effects on the heart when used with Norvi"...
Invirase Patient Information including If I Miss a Dose
In this Article
- What is saquinavir (Invirase)?
- What are the possible side effects of saquinavir (Invirase)?
- What is the most important information I should know about saquinavir (Invirase)?
- What should I discuss with my healthcare provider before taking saquinavir (Invirase)?
- How should I take saquinavir (Invirase)?
- What happens if I miss a dose (Invirase)?
- What happens if I overdose (Invirase)?
- What should I avoid while taking saquinavir (Invirase)?
- What other drugs will affect saquinavir (Invirase)?
- Where can I get more information?
What happens if I miss a dose (Invirase)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Invirase)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking saquinavir (Invirase)?
Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
What other drugs will affect saquinavir (Invirase)?
Many drugs can interact with saquinavir. Below is just a partial list. Tell your doctor if you are using:
- atorvastatin (Lipitor, Caduet);
- digoxin (digitalis, Lanoxin);
- dexamethasone (DexPak, Cortastat, Dexasone, Solurex) and other steroids;
- fluticasone (Advair, Flonase, Flovent);
- garlic or St. John's wort;
- methadone (Diskets, Dolophine, Methadose);
- omeprazole (Prilosec);
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), and others;
- antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
- any other HIV/AIDS medication;
- a blood thinner such as warfarin (Coumadin, Jantoven);
- an antidepressant such as amitriptyline (Elavil, Etrafon), desipramine (Norpramin), or imipramine (Janimine, Tofranil);
- drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf); or
- heart or blood pressure medication such as amlodipine (Caduet, Lotrel, Norvasc), diltiazem (Cartia, Cardizem), felodipine (Plendil), isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Nifedical, Procardia), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan);
- heart rhythm medication such as disopyramide (Norpace), ibutilide (Corvert), procainamide (Pronestyl), or sotalol (Betapace);
- medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
- a sedative such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), or flurazepam (Dalmane); or
- seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin).
This list is not complete and there are many other drugs that can interact with saquinavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about saquinavir.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Invirase Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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