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Invirase

"The U.S. Food and Drug Administration today announced that new safety information has been added to the label for the HIV antiviral drug Invirase (saquinavir), describing potentially life-threatening side effects on the heart when used with Norvi"...

Invirase

Invirase Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking saquinavir (Invirase)?

You should not take this medication if you are allergic to saquinavir or ritonavir (Norvir, Kaletra).

Life-threatening side effects may occur if you take saquinavir with:

  • amiodarone (Cordarone, Pacerone);
  • cisapride (Propulsid);
  • flecainide (Tambocor);
  • lovastatin (Mevacor, Altoprev, Advicor) or simvastatin (Zocor, Simcor, Vytorin);
  • midazolam (Versed) or triazolam (Halcion);
  • pimozide (Orap);
  • propafenone (Rythmol);
  • quinidine (Quin-G);
  • rifampin (Rifater, Rifadin, Rifamate); or
  • an ergot medicine such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

To make sure you can safely take saquinavir, tell your doctor if you have any of these other conditions:

  • liver disease;
  • heart disease, heart rhythm disorder, or a history of Long QT syndrome;
  • diabetes;
  • hemophilia; or
  • high cholesterol or triglycerides.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby, but HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

Saquinavir can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking saquinavir.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Do not give this medication to a child younger than 16 years old without the advice of a doctor.

How should I take saquinavir (Invirase)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Saquinavir must be taken together with another medication called ritonavir (Norvir).

Take saquinavir and ritonavir with food or within 2 hours after eating a full meal.

To be sure saquinavir is helping your condition, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

Use saquinavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Side Effects Centers
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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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