"A class of medications long used to curb HIV infection shows promise as a therapy for age-related macular degeneration (AMD), suggest findings from an NIH-funded study. These mainstay HIV drugs, called nucleoside reverse transcriptase inhibitors "...
(apraclonidine ophthalmic solution)
0.5% As Base
IOPIDINE® 0.5% Ophthalmic Solution contains apraclonidine hydrochloride, an alpha adrenergic agonist, in a sterile isotonic solution for topical application to the eye. Apraclonidine hydrochloride is a white to off-white powder and is highly soluble in water. Its chemical name is 2-[(4-amino-2,6 dichlorophenyl) imino]imidazolidine monohydrochloride with an empirical formula of C9H11Cl3N4 and a molecular weight of 281.57. The chemical structure of apraclonidine hydrochloride is:
Each mL of IOPIDINE 0.5% Ophthalmic Solution contains
Active: apraclonidine hydrochloride 5.75 mg equivalent to apraclonidine base 5 mg; Preservative: benzalkonium chloride 0.01%. Inactives: sodium chloride, sodium acetate, sodium hydroxide and/or hydrochloric acid (pH 4.4-7.8) and purified water.
What are the possible side effects of apraclonidine ophthalmic (Iopidine)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- slow or uneven heart rate;
- pounding heartbeats or fluttering in your chest;
- shallow breathing, feeling like you might pass out;
- severe swelling, redness, or discomfort in or around your eye;
- eye pain or increased watering; or
- numbness or tingly feeling in your hands or...
What are the precautions when taking apraclonidine (Iopidine Eye)?
Before using apraclonidine, tell your doctor or pharmacist if you are allergic to it; or to clonidine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel disease (e.g., cerebrovascular disease, Raynaud's disease), high blood pressure, heart problems (e.g., recent heart attack), kidney disease, mental/mood disorders (e.g., depression).
After you apply this drug, your vision may become temporarily blurred or unstable. It may also infrequently make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness...
Last reviewed on RxList: 1/24/2005
This monograph has been modified to include the generic and brand name in many instances.
Additional Iopidine Eye Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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