Iopidine Eye (Apraclonidine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Iopidine Eye

Glaucoma »

What is glaucoma?

Glaucoma is a disease of the major nerve of vision, called the optic nerve. The optic nerve receives light-generated nerve impulses from the retina and transmits these to the brain, where we recognize those electrical signals as vision. Glaucoma is characterized by a particular pattern of progressive damage to the optic nerve that generally begins with a subtle loss of side vision (peripheral vision). If glaucoma is not diagnosed and treated, it can progress to loss of central vision and blindness.

Glaucoma is usually, but not always, associated with elevated pressure in the eye (intraocular pressure). Generally, it is this elevated eye pressure that leads to damage of the eye (optic) nerve. In some cases, glaucoma may occur in the presence of normal eye pressure. This form of glaucoma is believed to be caused by poor regulation of blood flow to the optic nerve.

How common is glaucoma?

Worldwide, glaucoma...

Read the Glaucoma article »

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Iopidine Eye

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IOPIDINE® 0.5%
(apraclonidine ophthalmic solution)
0.5% As Base

DRUG DESCRIPTION

IOPIDINE® 0.5% Ophthalmic Solution contains apraclonidine hydrochloride, an alpha adrenergic agonist, in a sterile isotonic solution for topical application to the eye. Apraclonidine hydrochloride is a white to off-white powder and is highly soluble in water. Its chemical name is 2-[(4-amino-2,6 dichlorophenyl) imino]imidazolidine monohydrochloride with an empirical formula of C₉H₁₁C_l3N₄ and a molecular weight of 281.57. The chemical structure of apraclonidine hydrochloride is:

Each mL of IOPIDINE 0.5% Ophthalmic Solution contains

Active: apraclonidine hydrochloride 5.75 mg equivalent to apraclonidine base 5 mg; Preservative: benzalkonium chloride 0.01%. Inactives: sodium chloride, sodium acetate, sodium hydroxide and/or hydrochloric acid (pH 4.4-7.8) and purified water.

What are the possible side effects of apraclonidine ophthalmic (Iopidine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

slow or uneven heart rate;
pounding heartbeats or fluttering in your chest;
shallow breathing, feeling like you might pass out;
severe swelling, redness, or discomfort in or around your eye;
eye pain or increased watering; or

Read All Potential Side Effects and See Pictures of Iopidine Eye »

What are the precautions when taking apraclonidine (Iopidine Eye)?

Before using apraclonidine, tell your doctor or pharmacist if you are allergic to it; or to clonidine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood vessel disease (e.g., cerebrovascular disease, Raynaud's disease), high blood pressure, heart problems (e.g., recent heart attack), kidney disease, mental/mood disorders (e.g., depression).

After you apply this drug, your vision may become temporarily blurred or unstable. It may also infrequently make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness...

Read All Potential Precautions of Iopidine Eye »

Last reviewed on RxList: 1/24/2005
This monograph has been modified to include the generic and brand name in many instances.