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Iopidine Eye Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Iopidine 0.5% (apraclonidine) is used to treat or prevent high pressure inside the eye caused by certain types of eye surgery or procedures. It is an alpha-adrenergic agonist, which decreases the amount of fluid in the eye, decreasing pressure in the eye. This medication is available in generic form. Common side effects include eye discomfort/redness/burning, blurred vision, dry mouth/nose, dizziness, drowsiness, upset stomach, or unusual tiredness. Eye itching/watering or eyelid swelling may be symptoms of an allergic reaction of the eye.
The dose of Iopidine Ophthalmic Solution is one to two drops instilled in the affected eye(s) three times daily. Since Iopidine will be used with other ocular glaucoma therapies, wait at least 5 minutes between uses of each medication. Iopidine may interact with blood pressure medications, or heart rhythm medication. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Iopidine should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Our Iopidine 0.5% (apraclonidine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Iopidine Eye in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- slow or uneven heart rate;
- pounding heartbeats or fluttering in your chest;
- shallow breathing, feeling like you might pass out;
- severe swelling, redness, or discomfort in or around your eye;
- eye pain or increased watering; or
- numbness or tingly feeling in your hands or feet.
Less serious side effects may include:
- burning, itching, or dryness of your eyes;
- feeling like something is in your eye;
- blurred or dimmed vision;
- redness of the eye or eyelid;
- mildly swollen or puffy eyes;
- nausea, stomach pain, diarrhea;
- headache, sleep problems (insomnia);
- dry or stuffy nose, burning in your nose;
- a dry mouth; or
- unusual or unpleasant taste in your mouth.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Iopidine Eye (Apraclonidine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Iopidine Eye Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., depression, irritability), slow/irregular heartbeat.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Iopidine Eye (Apraclonidine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Iopidine Eye FDA Prescribing Information: Side Effects
In clinical studies the overall discontinuation rate related to IOPIDINE 0.5% Ophthalmic Solution was 15%. The most commonly reported events leading to discontinuation included (in decreasing order of frequency) hyperemia, pruritus, tearing, discomfort, lid edema, dry mouth, and foreign body sensation.
The following adverse reactions (incidences) were reported in clinical studies of IOPIDINE 0.5% (apraclonidine ophthalmic solution) as being possibly, probably, or definitely related to therapy:
The following adverse reactions were reported in 5 to 15% of the patients: discomfort, hyperemia, and puritus. The following adverse reactions were reported in 1 to 5% of the patients: blanching, blurred vision, conjunctivitis, discharge, dry eye, foreign body sensation, lid edema, and tearing.
The following adverse reactions were reported in less than 1% of the patients: abnormal vision, blepharitis, blepharoconjunctivitis, conjunctival edema, conjunctival follicles, corneal erosion, corneal infiltrate, corneal staining, edema, irritation, keratitis, keratopathy, lid disorder, lid erythema, lid margin crusting, lid retraction, lid scales, pain, photophobia.
Dry mouth occurred in approximately 10% of the patients.
The following adverse reactions were reported in less than 3% of the patients: abnormal coordination, asthenia, arrhythmia, asthma, chest pain, constipation, contact dermatitis, depression, dermatitis, dizziness, dry nose, dyspnea, facial edema, headache, insomnia, malaise, myalgia, nausea, nervousness, paresthesia, parosmia, peripheral edema, pharyngitis, rhinitis, somnolence, and taste perversion.
The following events have been identified during post-marketing use of IOPIDINE® 0.5% (apraclonidine) Ophthalmic Solution in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to IOPIDINE 0.5% Ophthalmic Solution, or a combination of these factors, include: bradycardia.
Read the entire FDA prescribing information for Iopidine Eye (Apraclonidine)
Additional Iopidine Eye Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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