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There were no instances of overdosage with IPLEX (mecasermin rinfabate [rdna origin] injection) in the Primary IGFD clinical trial. Based on the known pharmacological effects of IGF-1, acute overdosage could lead to hypoglycemia. Treatment of acute overdosage of IPLEX (mecasermin rinfabate [rdna origin] injection) should be directed at reversing hypoglycemia. Mild hypoglycemia can usually be treated with oral glucose or food. If the overdose results in loss of consciousness, treatment with parenteral glucagon or intravenous glucose may be required.

Long-term overdosage could result in signs and/or symptoms of acromegaly.


IPLEX (mecasermin rinfabate [rDNA origin] injection) should not be used for growth promotion in patients with closed epiphyses.

IPLEX (mecasermin rinfabate [rdna origin] injection) is contraindicated in the presence of active or suspected neoplasia, and therapy should be discontinued when there is any evidence of active neoplasia.

IPLEX (mecasermin rinfabate [rdna origin] injection) is contraindicated in patients allergic to mecasermin rinfabate (rhIGF-1/rhIGFBP-3) or any of the excipients in IPLEX (mecasermin rinfabate [rdna origin] injection) .

Intravenous administration of IPLEX (mecasermin rinfabate [rdna origin] injection) is contraindicated.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 3/2/2009


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