"Two novel products for the treatment of non-small-cell lung cancer (NSCLC) have been recommended for approval in Europe: osimertinib (Tagrisso, AstraZeneca) and necitumumab (Portrazza, Eli Lilly).
Twenty three patients were treated weekly with doses from 1500 mg to 3500 mg, and IRESSA exposure did not increase with increasing dose. Adverse events were mostly mild to moderate in severity, and were consistent with the known safety profile of IRESSA. In the event of suspected overdose, interrupt IRESSA, institute supportive care, and observe until clinical stabilization. There are no specific measures/treatments that should be taken following IRESSA overdosing.
None.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 7/15/2015
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