"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing of selexipag (Uptravi, Actelion Registration Ltd) for the treatment of adults with pulmonary arterial hypertension (PAH)./"...
(Generic versions may still be available.)
The following adverse reactions have been observed but there are not enough data to support an estimate of their frequency. Consequently the reactions are categorized by organ system and are listed in decreasing order of severity and not frequency.
Neurologic: Syncope resulting from either postural or exertional hypotension; dizziness; blurred vision; muscle tremor; ptosis of the lids; mental depression; chest paresthesias; weakness; lassitude; fatigue.
Metabolic: Weight gain
Read the Ismelin (guanethidine monosulfate) Side Effects Center for a complete guide to possible side effects
Concurrent use of Ismelin (guanethidine monosulfate) and rauwolfia derivatives may cause excessive postural hypotension, bradycardia, and mental depression.
Both digitalis and Ismelin (guanethidine monosulfate) slow the heart rate.
Amphetamine-like compounds, stimulants (e.g., ephedrine, methylphenidate), tricyclic antidepressants (e.g., amitriptyline, imipramine, desipramine) and other psychopharmacologic agents (e.g., phenothiazines and related compounds), as well as oral contraceptives, may reduce the hypotensive effect of Ismelin (guanethidine monosulfate) .
MAO inhibitors should be discontinued for at least 1 week before starting therapy with Ismelin (guanethidine monosulfate) . This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
Additional Ismelin Information
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