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(verapamil HCl) Sustained-Release Oral Tablets
ISOPTIN® SR (verapamil hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). ISOPTIN SR is available for oral administration as light green, capsule shaped, scored, film-coated tablets containing 240 mg verapamil hydrochloride, as light pink, oval shaped, scored, film-coated tablets containing 180 mg verapamil hydrochloride, and as light violet, oval-shaped, film-coated tablets containing 120 mg verapamil hydrochloride.The tablets are designed for sustained-release of the drug in the gastrointestinal tract, sustained- release characteristics are not altered when the tablet is divided in half.
The structural formula of verapamil HCl is given below
C27H38N2O4•HCl............. M.W. 491.08
Benzeneacetronitrile, α [3-[[2-(3,4-dimethoxyphenyl) ethyl] methylamino] propyl]-3,4dimethoxy-α-(1-methylethyl) hydrochloride
Verapamil HCl is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil HCl is not chemically related to other cardioactive drugs.
In addition to verapamil HCl, the ISOPTIN SR tablet contains the following ingredients: alginate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl pyrrolidone, talc, and titanium dioxide. The following are the color additives per tablet strength:
|Strength (mg)||Color Additive(s)|
|240||D&C yellow #10 Lake dye, and FD&C blue #2 Lake dye|
What are the possible side effects of verapamil?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- fast or slow heartbeats;
- feeling like you might pass out;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
- restless muscle movements in your eyes, tongue, jaw, or neck;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain; or
- nausea, stomach...
What are the precautions when taking verapamil hydrochloride tablet (Isoptin SR)?
Before taking verapamil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart rhythm problems (such as second- or third-degree atrioventricular block, sick sinus syndrome unless you have a pacemaker, Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, heart failure, certain muscle/nerve...
Last reviewed on RxList: 12/16/2011
This monograph has been modified to include the generic and brand name in many instances.
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