home > drugs a-z list > isopto carpine (pilocarpine) drug center > isopto carpine (pilocarpine) drug - overdosage and contraindications

Systemic toxicity following topical ocular administration of pilocarpine is rare, but occasionally patients who are sensitive may develop sweating and gastrointestinal overactivity following the suggested dosage and administration. Overdosage can produce sweating, salivation, nausea, tremors and slowing of the pulse and a decrease in blood pressure. In moderate overdosage, spontaneous recovery is to be expected and is aided by intravenous fluids to compensate for dehydration. For patients demonstrating severe poisoning, atropine, the pharmacologic antagonist to pilocarpine, should be used.

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Last reviewed on RxList: 7/21/2010
This monograph has been modified to include the generic and brand name in many instances.