Isopto® Carpine (pilocarpine hydrochloride ophthalmic solution) is a cholinergic agonist prepared as a sterile topical ophthalmic solution. The active ingredient is represented by the chemical structure:

Established name: pilocarpine hydrochloride Chemical name: 2(3H)-furanone, 3­ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)­methyl]-monohydrochloride, (3S-cis)-.

Molecular Formula: C₁₁H₁₆N₂O₂ •HCl

Molecular Weight: 244.72

Each mL of Isopto Carpine (pilocarpine hydrochloride ophthalmic solution) contains: Active: pilocarpine hydrochloride 1% (10 mg/mL), 2% (20 mg/mL), or 4% (40 mg/mL). Preservative: benzalkonium chloride 0.01%. Inactives: hypromellose 2910, boric acid, sodium citrate, sodium chloride (present in 1% only); hydrochloric acid and/or sodium hydroxide (to adjust pH); purified water. Isopto® Carpine (pilocarpine) has a pH of 3.5 to 5.5 and an osmolality of 290 to 350 mOsm/kg (1% and 2% products) and 550 to 600 mOsm/kg (4% product).

Last reviewed on RxList: 7/21/2010
This monograph has been modified to include the generic and brand name in many instances.