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Patients should be advised to exercise caution in night driving and other hazardous occupations in poor illumination. In addition, miotics may cause accommodative spasm.
Patients should be advised not to drive or use machinery if vision is not clear.
Pre-existing Retinal Disease
As with all miotics, rare cases of retinal detachment have been reported when used in certain susceptible individuals and those with pre-existing retinal disease; therefore, a thorough examination of the retina including funduscopy is advised in all patients prior to the initiation of therapy.
Isopto® Carpine (pilocarpine) is not recommended to be used when iritis is present.
Primary Congenital Glaucoma
Caution is advised when using Isopto® Carpine (pilocarpine) in pediatric patients with primary congenital glaucoma for control of intraocular pressure (IOP) as cases of a paradoxical increase in IOP have been reported. In addition, the use of Isopto® Carpine (pilocarpine) is not recommended in pediatric patients diagnosed with glaucoma secondary to anterior segment dysgenesis or uveitis (especially if uveitis is active).
Contact Lens Wear
Contact lens wearers should be advised to remove their lenses prior to the instillation of Isopto® Carpine (pilocarpine) ophthalmic solution and to wait 10 minutes after dosing before reinserting their contact lenses.
Carcinogenesis, Mutagenesis, Impairment of Fertility
There have been no long-term studies done using pilocarpine hydrochloride in animals to evaluate carcinogenic potential.
Use In Specific Populations
Pregnancy. Category C. Animal reproduction studies have not been conducted with pilocarpine hydrochloride. It is also not known whether pilocarpine hydrochloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Isopto® Carpine (pilocarpine) should be given to a pregnant woman only if clearly needed.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Isopto® Carpine (pilocarpine) is administered to a nursing woman.
Safety and effectiveness of pilocarpine hydrochloride ophthalmic solution in pediatric patients have been established.
No overall differences in safety or effectiveness have been observed between elderly and younger patients.
Last reviewed on RxList: 7/21/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Isopto Carpine Information
- Isopto Carpine Drug Interactions Center: pilocarpine hcl opht
- Isopto Carpine Side Effects Center
- Isopto Carpine Overview including Precautions
- Isopto Carpine FDA Approved Prescribing Information including Dosage
Isopto Carpine - User Reviews
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