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Isordil

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Angina facts

  • Angina is one of many causes of chest pain.
  • Angina is chest pain that is a result of inadequate oxygen supply to the heart muscle.
  • Angina can be caused by coronary artery disease or spasm of the coronary arteries.
  • Electrocardiogram (ECG or EKG), exercise stress test, stress echocardiography, stress thallium, and cardiac catheterization are important in the diagnosis of angina.
  • Treatment of angina includes rest, medications, angioplasty, and/or coronary artery bypass surgery.

Introduction to angina

Angina is one of the serious causes of chest pain. “Angina” is an abbreviation of angina pectoris, a Latin term for “squeezing of the chest.” Chest pain is a common symptom caused by many different conditions. Some causes require prompt medical attention, such as angina, heart attack, blood clots i...

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Isordil

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Isordil® Titradose®
(isosorbide dinitrate) Tablets

DRUG DESCRIPTION

Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is

Isordil (isosorbide dinitrate) structural formula illustration

and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Each Isordil (isosorbide dinitrate) ® Titradose® tablet contains 5 or 40 mg of isosorbide dinitrate. The inactive ingredients in each tablet are - lactose, cellulose, and magnesium stearate. The 5 mg and 40 mg dosage strengths also contain the following: 5 mg - FD&C Red 40; 40 mg - D&C Yellow 10, FD&C Blue 1, and FD&C Yellow 6.

What are the possible side effects of isosorbide dinitrate (Dilatrate-SR, Isochron, Isordil Titradose)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, slow, pounding, or uneven heart rate;
  • worsening angina pain;
  • blurred vision or dry mouth;
  • nausea, vomiting, sweating, pale skin, feeling like you might pass out; or
  • blue-colored skin, tiredness, and feeling...

Read All Potential Side Effects and See Pictures of Isordil »

Last reviewed on RxList: 5/6/2008
This monograph has been modified to include the generic and brand name in many instances.

Additional Isordil Information

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