November 24, 2015
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Isordil® Titradose™
(isosorbide dinitrate) Tablets


Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is

Isordil® Titradose™ (isosorbide dinitrate)  Structural Formula Illustration

and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Each Isordil® Titradose™ tablet contains 5 or 40 mg of isosorbide dinitrate. The inactive ingredients in each tablet are lactose, cellulose, and magnesium stearate. The 5 mg and 40 mg dosage strengths also contain the following: 5 mg – FD&C Red 40; 40 mg – D&C Yellow 10, FD&C Blue 1, and FD&C Yellow 6.

What are the possible side effects of isosorbide dinitrate (Dilatrate-SR, Isochron, Isordil Titradose)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, slow, pounding, or uneven heart rate;
  • worsening angina pain;
  • blurred vision or dry mouth;
  • nausea, vomiting, sweating, pale skin, feeling like you might pass out; or
  • blue-colored skin, tiredness, and feeling short of breath.

Less serious side effects may...

Read All Potential Side Effects and See Pictures of Isordil »

Last reviewed on RxList: 1/27/2015
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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