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(isosorbide dinitrate) Tablets
Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is
and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.
Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.
Each Isordil® Titradose™ tablet contains 5 or 40 mg of isosorbide dinitrate. The inactive ingredients in each tablet are lactose, cellulose, and magnesium stearate. The 5 mg and 40 mg dosage strengths also contain the following: 5 mg – FD&C Red 40; 40 mg – D&C Yellow 10, FD&C Blue 1, and FD&C Yellow 6.
What are the possible side effects of isosorbide dinitrate (Dilatrate-SR, Isochron, Isordil Titradose)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fast, slow, pounding, or uneven heart rate;
- worsening angina pain;
- blurred vision or dry mouth;
- nausea, vomiting, sweating, pale skin, feeling like you might pass out; or
- blue-colored skin, tiredness, and feeling short of breath.
Less serious side effects may...
Last reviewed on RxList: 1/27/2015
This monograph has been modified to include the generic and brand name in many instances.
Additional Isordil Information
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