Isordil (Isosorbide Dinitrate) Drug Overview and Uses for Patients and Caregivers at RxList

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May 27, 2012

Isordil

Angina »

Angina facts

Angina is one of many causes of chest pain.
Angina is chest pain that is a result of inadequate oxygen supply to the heart muscle.
Angina can be caused by coronary artery disease or spasm of the coronary arteries.
Electrocardiogram (ECG or EKG), exercise stress test, stress echocardiography, stress thallium, and cardiac catheterization are important in the diagnosis of angina.
Treatment of angina includes rest, medications, angioplasty, and/or coronary artery bypass surgery.

Introduction to angina

Angina is one of the serious causes of chest pain. “Angina” is an abbreviation of angina pectoris, a Latin term for “squeezing of the chest.” Chest pain is a common symptom caused by many different conditions. Some causes require prompt medical attention, such as angina, heart attack, blood clots i...

Read the Angina article »

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Isordil

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Isordil® Titradose®
(isosorbide dinitrate) Tablets

DRUG DESCRIPTION

Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is

Isordil (isosorbide dinitrate) structural formula illustration

and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Each Isordil (isosorbide dinitrate) ® Titradose® tablet contains 5 or 40 mg of isosorbide dinitrate. The inactive ingredients in each tablet are - lactose, cellulose, and magnesium stearate. The 5 mg and 40 mg dosage strengths also contain the following: 5 mg - FD&C Red 40; 40 mg - D&C Yellow 10, FD&C Blue 1, and FD&C Yellow 6.

Last reviewed on RxList: 5/6/2008
This monograph has been modified to include the generic and brand name in many instances.