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(iopamidol) Injection 41%

(iopamidol) Injection 61%


For Intrathecal Administration in Neuroradiology Including Myelography (Lumbar, Thoracic, Cervical, Total Columnar) Pediatric Myelography (Lumbar, Thoracic), and for Contrast Enhancement of Computed Tomographic (CECT) Cisternography and Ventriculography


ISOVUE-M (lopamidol Injection) formulations are stable, aqueous, sterile, and nonpyrogenic solutions for intrathecal administration.

Each mL of ISOVUE-M 200 (lopamidol Injection 41%) provides 408 mg iopamidol with 1 mg tromethamine and 0.26 mg edetate calcium disodium. The solution contains approximately 0.029 mg (0.001 mEq) sodium and 200 mg organically bound iodine per mL.

Each mL of ISOVUE-M 300 (lopamidol Injection 61%) provides 612 mg iopamidol with 1 mg tromethamine and 0.39 mg edetate calcium disodium. The solution contains approximately 0.043 mg (0.002 mEq) sodium and 300 mg organically bound iodine per mL.

The pH of ISOVUE-M contrast media has been adjusted to 6.5-7.5 with hydrochloric acid and/or sodium hydroxide. Pertinent physicochemical data are noted below. ISOVUE-M (lopamidol Injection) is hypertonic as compared to plasma and cerebrospinal fluid (approximately 285 and 301 mOsm/kg water, respectively).

Parameter 41% 61%
Concentration(mgl/mL) 200 300
Osmolality @ 37° C (mOsm/kg water) 413 616
Viscosity (cP) @ 37° C 2.0 4.7
@ 20° C 3.3 8.8
Specific Gravity @ 37° C 1.216 1.328

lopamidol is designated chemically as (S)-N,N'-bis[2-hydroxy-1-(hydroxymethyl)-ethyl]- 2,4,6-triiodo-5lactamidoisophthalamide. Structural formula:

ISOVUE-M (lopamidol Injection) Structural Formula Illustration

Last reviewed on RxList: 8/28/2012
This monograph has been modified to include the generic and brand name in many instances.

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