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There have been reports of inadvertent overdosage with ISTALOL (timolol maleate ophthalmic solution) ophthalmic solution resulting in systemic effects similar to those seen with systemic beta-adrenergic blocking agents such as dizziness, headache, shortness of breath, bradycardia, bronchospasm, and cardiac arrest (see also ADVERSE REACTIONS).
An in vitro hemodialysis study, using 14C timolol added to human plasma or whole blood, showed that timo-lol was readily dialyzed from these fluids; however, a study of patients with renal failure showed that timolol did not dialyze readily.
ISTALOL (timolol maleate ophthalmic solution) is contraindicated in patients with (1) bronchial asthma; (2) a history of bronchial asthma; (3) severe chronic obstructive pulmonary disease (see WARNINGS); (4) sinus bradycardia; (5) second or third degree atrioventricular block; (6) overt cardiac failure (see WARNINGS); (7) cardiogenic shock; or (8) hypersensitivity to any component of this product.
Last reviewed on RxList: 3/27/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Istalol Information
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