Ixiaro (Japanese Encephalitis Vaccine) Drug Overview and Uses for Patients and Caregivers at RxList

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May 27, 2012

Ixiaro

Meningitis »

Encephalitis and meningitis facts

Encephalitis is an inflammation of the brain.
Meningitis is an inflammation of the membranes (called meninges) that surround the brain and spinal cord.
Anyone experiencing symptoms of encephalitis or meningitis should see a doctor immediately.

What is encephalitis?

Encephalitis is an inflammation of the brain. There are many types of encephalitis, most of which are caused by infections. Most often these infections are caused by viruses. In addition to infections, encephalitis can also be caused by certain diseases that result in an inflammation of the brain.

What are encephalitis symptoms and signs?

The signs and symptoms of encephalitis can range from very mild symptoms to potentially life-threatening. Signs and symptoms of encephalitis include sudden fever, headache, vomiting, visual sensitivity to light, stiff neck an...

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Ixiaro

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IXIARO
(japanese encephalitis vaccine, inactivated, adsorbed) Suspension for Intramuscular Injection

DRUG DESCRIPTION

IXIARO, Japanese Encephalitis Vaccine, Inactivated, Adsorbed is a sterile suspension for intramuscular injection. Each dose of vaccine contains approximately 6 mcg of purified, inactivated JEV proteins and 250 mcg of aluminum hydroxide. The appearance of the liquid is a white, opaque, non-uniform suspension which becomes homogeneous upon shaking. As IXIARO (japanese encephalitis vaccine) is inactivated, it cannot cause Japanese Encephalitis.

IXIARO (japanese encephalitis vaccine) is a vaccine prepared by propagating JEV strain SA₁₄-14-2 in Vero cells. Multiple viral harvests are performed, which are pooled, clarified and concentrated. The virus suspension is treated with protamine sulfate to remove contaminating DNA and proteins. The resulting partially purified virus is processed through a sucrose density gradient centrifugation step and fractionated. Each fraction is analyzed for the presence of virus, and fractions with the highest virus activity are pooled to give a purified virus suspension. The purified virus is then inactivated by treatment with formaldehyde. The preparation is adjusted to a specified protein concentration and formulated by addition of aluminum hydroxide.

The formulated bulk vaccine is filled into syringes, at a volume of 0.5 mL per syringe. From the manufacturing process, IXIARO (japanese encephalitis vaccine) also contains: formaldehyde (not more than 200 ppm), bovine serum albumin (not more than 100 ng/mL), host cell DNA (not more than 200 pg/mL), sodium metabisulphite (not more than 200 ppm), host cell proteins (not more than 300 ng/mL), and protamine sulfate (not more than 1μg/mL). No preservatives, stabilizers, or antibiotics are added to the formulation.

Last reviewed on RxList: 3/11/2010
This monograph has been modified to include the generic and brand name in many instances.