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Jakafi

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Jakafi

Jakafi Patient Information Including Side Effects

Brand Names: Jakafi

Generic Name: ruxolitinib (Pronunciation: RUX oh LI ti nib)

What is ruxolitinib (Jakafi)?

Ruxolitinib works by blocking certain enzymes in the body that affect blood cell production.

Ruxolitinib is used to treat myelofibrosis, a bone marrow disorder that affects your body's ability to produce blood cells.

Ruxolitinib may also be used for purposes not listed in this medication guide.

What are the possible side effects of ruxolitinib (Jakafi)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may be similar to the symptoms of myelofibrosis. Call your doctor at once if you have a serious side effect such as:

  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, chills, body aches, flu symptoms, vomiting, sores in your mouth and throat;
  • pain or burning when you urinate; or
  • blisters or painful skin rash.

Less serious side effects may include:

  • headache;
  • dizziness;
  • weight gain; or
  • bloating gas.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Jakafi (ruxolitinib) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about ruxolitinib (Jakafi)?

You should not use ruxolitinib if you are allergic to it, or if you have severe kidney disease.

Before you take ruxolitinib, tell your doctor if you have liver or kidney disease, if you are on dialysis, or if you are pregnant.

You should not breast-feed while you are using ruxolitinib.

Your doctor may occasionally change your dose to make sure you get the best results.

To be sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. This will help your doctor determine the best dose for you to use. When you first start taking ruxolitinib, your blood will need to be tested every 2 to 4 weeks. Do not miss any follow-up visits to your doctor.

Grapefruit and grapefruit juice may interact with ruxolitinib and can affect the amount of the medication in your blood. Discuss the use of grapefruit products with your doctor.

Do not stop using ruxolitinib without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Side Effects Centers
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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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