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There is no known antidote for JEVTANA overdose. Overdose has resulted from improper preparation [see DOSAGE AND ADMINISTRATION]. Read the entire section Dosage and Administration (2) carefully before mixing or diluting. Complications of overdose include exacerbation of adverse reactions such as bone marrow suppression and gastrointestinal disorders. Overdose has led to fatal outcome.

In case of overdose, the patient should be kept in a specialized unit where vital signs, chemistry and particular functions can be closely monitored. Patients should receive therapeutic G-CSF as soon as possible after discovery of overdose. Other appropriate symptomatic measures should be taken, as needed.


JEVTANA is contraindicated in patients with:

  • neutrophil counts of ≤1,500/mm3 [see WARNINGS AND PRECAUTIONS]
  • history of severe hypersensitivity reactions to cabazitaxel or to other drugs formulated with polysorbate 80 [see WARNINGS AND PRECAUTIONS]
  • severe hepatic impairment (total bilirubin >3 × ULN) [see WARNINGS AND PRECAUTIONS]
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 3/1/2017


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