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Juvisync

"The U.S. Food and Drug Administration today approved three new related products for use with diet and exercise to improve blood sugar control in adults with type 2 diabetes: Nesina (alogliptin) tablets, Kazano (alogliptin and metformin hydrochlor"...

Juvisync

Juvisync

Juvisync Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking simvastatin and sitagliptin (Juvisync)?

You should not use this medicine if you are allergic to simvastatin (Zocor) or sitagliptin (Januvia), if you have liver disease or severe kidney disease, or if you are pregnant or breast-feeding.

Do not use this medication if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

There are many other drugs that can cause serious or life threatening medical problems if you take them together with simvastatin and sitagliptin. The following drugs should not be used while you are taking simvastatin and sitagliptin:

  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • danazol (Danocrine);
  • gemfibrozil (Lopid);
  • nefazodone (an antidepressant);
  • the antibiotics clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), and telithromycin (Ketek);
  • the antifungal medications itraconazole (Sporanox), ketoconazole (Nizoral), and posaconazole (Noxafil); or
  • the HIV/AIDS medications atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), saquinavir (Invirase), and tipranavir (Aptivus).

Before you start taking simvastatin and sitagliptin, tell your doctor if you are already using any of these other medicines:

  • amiodarone (Cordarone, Pacerone);
  • amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide);
  • diltiazem (Cartia, Cardizem);
  • ranolazine (Ranexa); or
  • verapamil (Calan, Covera, Isoptin, Verelan).

To make sure you can safely take simvastatin and sitagliptin, tell your doctor if you have any of these other conditions:

  • a history of liver or kidney disease;
  • a history of pancreatitis;
  • underactive thyroid; or
  • if you drink more than 2 alcoholic beverages daily.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not take simvastatin and sitagliptin if you are pregnant. Stop taking the medicine and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking simvastatin and sitagliptin

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using simvastatin and sitagliptin.

How should I take simvastatin and sitagliptin (Juvisync)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Simvastatin and sitagliptin is usually taken once daily in the evening.

Do not crush, chew, or break the tablet. Swallow it whole.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.

Ask your doctor how to adjust your dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Simvastatin and sitagliptin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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