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Juvisync

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Juvisync

Juvisync Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking simvastatin and sitagliptin (Juvisync)?

You should not use this medicine if you are allergic to simvastatin or sitagliptin, if you have liver disease or severe kidney disease, or if you are pregnant or breast-feeding.

Do not use this medication if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

In rare cases, simvastatin and sitagliptin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Some medicines can cause unwanted or dangerous effects when used with simvastatin and sitagliptin. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • cyclosporine;
  • danazol;
  • gemfibrozil;
  • nefazodone;
  • the antibiotics clarithromycin, erythromycin, or telithromycin;
  • the antifungal medications itraconazole, ketoconazole, posaconazole, or voriconazole;
  • the hepatitis C medications boceprevir or telaprevir; or
  • the HIV/AIDS medications atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, or tipranavir.

Before you start taking simvastatin and sitagliptin, tell your doctor if you are already using any of these other medicines:

  • amiodarone or dronedarone;
  • amlodipine;
  • diltiazem;
  • ranolazine; or
  • verapamil.

To make sure simvastatin and sitagliptin is safe for you, tell your doctor if you have:

  • a history of liver or kidney disease;
  • a history of pancreatitis;
  • a history of gallstones;
  • underactive thyroid; or
  • a history of alcoholism.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not take simvastatin and sitagliptin if you are pregnant. Stop taking the medicine and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking simvastatin and sitagliptin.

It is not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are taking simvastatin and sitagliptin.

Do not give this medication to anyone under 18 years old without medical advice.

How should I take simvastatin and sitagliptin (Juvisync)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Simvastatin and sitagliptin is usually taken once daily in the evening.

Do not crush, chew, or break the tablet. Swallow it whole.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Simvastatin and sitagliptin is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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