"THOUSAND OAKS, CA â€” Evolocumab (Repatha, Amgen), a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor for lowering LDL cholesterol, effectively modifies atherosclerotic plaque buildup in coronary arteries of patients when ad"...
There is no specific treatment in the event of overdose of JUXTAPID. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. Liver-related tests should be monitored. Hemodialysis is unlikely to be beneficial given that lomitapide is highly protein bound.
JUXTAPID is contraindicated in the following conditions :
- Pregnancy [see WARNINGS AND PRECAUTIONS and Use in Specific Populations].
- Concomitant administration of JUXTAPID with moderate or strong CYP3A4 inhibitors, as this can increase JUXTAPID exposure [see WARNINGS AND PRECAUTIONS, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY].
- Patients with moderate or severe hepatic impairment (based on Child-Pugh category B or C) and patients with active liver disease, including unexplained persistent elevations of serum transaminases [see WARNINGS AND PRECAUTIONS and Use In Specific Populations].
Last reviewed on RxList: 1/11/2017
Additional Juxtapid Information
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