"By Megan Brooks
Medscape Medical News
The European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended approval of tolvaptan (Jinarc, Otuska) to slow progression of cyst developmen"...
- For the treatment of patients with hypokalemia with or without metabolic alkalosis, in digitalis intoxication, and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
- For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern, and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and, if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.
DOSAGE AND ADMINISTRATION
The usual dietary potassium intake by the average adult is 50 to 100 mEq per day. Potassium depletion sufficient to cause hypokalemia usually requires the loss of 200 or more mEq of potassium from the total body store.
Dosage must be adjusted to the individual needs of each patient. The dose for the prevention of hypokalemia is typically in the range of 20 mEq per day. Doses of 40-100 mEq per day or more are used for the treatment of potassium depletion. Dosage should be divided if more than 20 mEq per day is given such that no more than 20 mEq is given in a single dose. The dose should be taken after a meal.
K-LOR (potassium chloride) 20 mEq powder provides 20 mEq of potassium chloride.
Each 20 mEq (one K-LOR (potassium chloride) 20 mEq packet) of potassium should be dissolved in at least 4 oz (approximately 1/2 glassful) cold water or juice. This preparation, like other potassium supplements, must be properly diluted to avoid the possibility of gastrointestinal irritation.
K-LOR 20 mEq (Potassium Chloride for Oral Solution, USP) is supplied in cartons of 30 packets (NDC 0074-3611-01) and in cartons of 100 packets (NDC 0074-3611-02). Each packet contains potassium, 20 mEq, and chloride, 20 mEq, provided by potassium chloride, 1.5 g.
Recommended Storage: Store below 86°F (30°C).
Revised: April, 2006. Abbott Laboratories. North Chicago, IL 60064, U.S.A.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/28/2009
Additional K-LOR Information
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