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Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

Lopinavir/ritonavir interacts with many medications. Other medications can affect the removal of lopinavir/ritonavir from your body, which may affect how lopinavir/ritonavir works. In addition, lopinavir/ritonavir can slow down or speed up the removal of other medications from your body, which may affect how they work. Before taking lopinavir/ritonavir, tell your doctor or pharmacist about all medications and products you may use.

This drug should not be used with the following medications because very serious interactions may occur: alfuzosin, certain non-drowsy antihistamines, bosentan, cisapride, conivaptan, eletriptan, eplerenone, ergot drugs (e.g., dihydroergotamine, ergonovine, methylergonovine, ergotamine), ivabradine, pimozide, ranolazine, rifampin, certain sedatives (midazolam, triazolam), sildenafil (when used to treat pulmonary hypertension), certain "statins" (lovastatin, simvastatin), St John's wort, voriconazole.

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting lopinavir/ritonavir.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other HIV drugs (e.g., efavirenz, amprenavir, zidovudine, abacavir, nevirapine, atazanavir, tipranavir/ritonavir), antidepressants (e.g., bupropion, trazodone), atovaquone, other azole antifungals (ketoconazole, itraconazole), "blood thinners" (e.g., warfarin), calcium channel blockers (e.g., felodipine, nifedipine, nicardipine), some cancer drugs (e.g., dasatinib, lapatinib, sunitinib, vinblastine, vincristine), dexamethasone, disulfiram, drugs for erectile dysfunction/drugs to treat pulmonary hypertension (e.g., sildenafil, tadalafil, vardenafil), certain inhaled drugs to treat breathing problems (e.g., fluticasone, salmeterol), garlic supplements, heart rhythm medication (e.g., amiodarone, bepridil, lidocaine, quinidine), drugs that suppress the immune system (e.g., cyclosporine, tacrolimus, rapamycin), macrolide antibiotics (e.g., clarithromycin), metronidazole, narcotic pain medications (e.g., methadone), rifabutin, other sedatives (alprazolam, zolpidem), seizure medication (e.g., phenytoin, carbamazepine, phenobarbital), solifenacin, certain other "statins" (atorvastatin, rosuvastatin), temsirolimus.

Many drugs besides lopinavir/ritonavir may affect the heart rhythm (QT prolongation), including dofetilide, procainamide, sotalol, among others.

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. However, to reduce the risk of spreading HIV to others, always use barrier protections during all sexual activity. (See also Notes section.)

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), muscle relaxants, psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include numbness or tingling in the arms, hands, legs, or feet, a change in amount of urine, severe drowsiness/dizziness, loss of consciousness, or shallow breathing.

Due to the high alcohol content of lopinavir/ritonavir solution, children accidentally drinking the medication may have a serious, possibly fatal reaction. If a child accidentally drinks this product, contact your local poison control center or emergency room immediately.

NOTES: To decrease your risk of spreading HIV disease, always use an effective barrier method (e.g., latex condoms/dental dams) during sexual activity. Consult your doctor or pharmacist for more details.

Do not share this medication with others.

Keep all medical and laboratory appointments. Laboratory and/or medical tests (e.g., liver function, blood counts, blood cholesterol/triglyceride levels, blood sugar) should be performed from time to time to monitor your progress or check for side effects. Consult your doctor for more details.

Lopinavir/ritonavir is available in tablets, capsules and oral solution. Do not switch types of this medication without instructions on how to do so by your doctor.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Refrigerate between 36-46 degrees F (2-8 degrees C) away from light and moisture. If stored at room temperature (77 degrees F or 25 degrees C), this product should be used within 2 months. Avoid exposure to high heat. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).

Information last revised May 2011 Copyright(c) 2011 First DataBank, Inc.