November 30, 2015
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Karbinal ER

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Karbinal ER



Overdosage with carbinoxamine may cause central nervous system depression or stimulation, hallucinations, convulsions, and death. Atropine-like signs and symptoms – dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur.

The treatment of overdosage consists of discontinuation of Karbinal ER and institution of symptomatic and supportive therapy. Vital signs (including respiration, pulse, blood pressure, and temperature) and EKG should be monitored. Induction of vomiting is not recommended. Activated charcoal should be given and gastric lavage should be considered after ingestion of a potentially life-threatening amount of drug. In the presence of severe anticholinergic effects, physostigmine may be useful. Vasopressors may be used to treat hypotension.


Children less than 2 years of age

Karbinal ER is contraindicated in children younger than 2 years of age because deaths have been reported in this age group [see WARNINGS AND PRECAUTIONS].

Nursing Mothers

Karbinal ER is contraindicated in nursing mothers because of the risk of mortality in infants given carbinoxamine-containing products [see Use in Specific Populations].


Karbinal ER is contraindicated in patients who are hypersensitive to carbinoxamine maleate or any of the inactive ingredients in Karbinal ER [see WARNINGS AND PRECAUTIONS].

Monoamine oxidase inhibitors

Karbinal ER is contraindicated in patients who are taking monoamine oxidase inhibitors (MAOI) [see DRUG INTERACTIONS].

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 4/15/2013


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