"The U.S. Food and Drug Administration today granted accelerated approval to Praxbind (idarucizumab) for use in patients who are taking the anticoagulant Pradaxa (dabigatran) during emergency situations when there is a need to reverse Pradaxa&rsqu"...
Overdosage may result in electrolyte disturbances including hypokalemia, hypocalcemia, and hypomagnesemia. Biochemical disturbances resulting from overdosage may give rise to clinical signs and symptoms of hypokalemia, including: irritability, confusion, delayed thought processes, muscle weakness, hyporeflexia, which may progress to frank paralysis and/or apnea. Tetany may occur. Electrocardiographic changes may be consistent with hypokalemia or hypocalcemia; cardiac arrhythmias may occur. Appropriate measures should be taken to correct serum electrolytes (potassium, calcium, magnesium), and the resin should be removed from the alimentary tract by appropriate use of laxatives or enemas.
Kayexalate (sodium polystyrene) is contraindicated in the following conditions: patients with hypokalemia, patients with a history of hypersensitiviry to polystyrene sulfonate resins, obstructive bowel disease, neonates with reduced gut motiliry (postoperatively or drug induced) and oral administration in neonates (see PRECAUTIONS).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 2/28/2011
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