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Kayexalate Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Kayexalate (sodium polystyrene) is a cation-exchange resin used to treat high levels of potassium in the blood, also called hyperkalemia. It works by works by helping your body get rid of extra potassium. Kayexalate is available in generic form. Common side effects of Kayexalate include loss of appetite, upset stomach, nausea, vomiting, or constipation. Diarrhea may occur less frequently.
The average daily adult dose of Kayexalate is 15 g to 60 g, taken as 15 g (approximately 4 level teaspoons) one to four times daily. Kayexalate may interact with digoxin, lithium, thyroxine, or diuretics (water pills). Tell your doctor all medications you use. During pregnancy, Kayexalate should be used only when prescribed. It is unknown if this drug passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.
Our Kayexalate (sodium polystyrene) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Kayexalate in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers right away if you have any of these serious side effects:
- pain or fluttering in your chest;
- uneven heartbeats;
- feeling irritable or confused;
- increased thirst or urination;
- severe muscle weakness;
- inability to move your muscles;
- black, bloody, or tarry stools;
- pain in your lower stomach or rectum; or
- swelling, rapid weight gain.
Less serious side effects may include:
- diarrhea or constipation;
- nausea or vomiting;
- upset stomach; or
- loss of appetite.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Kayexalate (Sodium Polystyrene)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Kayexalate Overview - Patient Information: Side Effects
To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise, unless otherwise directed by your doctor. Severe constipation can become very serious. Consult your doctor or pharmacist for help in selecting a laxative. Certain laxatives should not be taken with this medication. See the Drug Interactions section.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: muscle weakness/spasms, fast/irregular heartbeat, mental/mood changes (such as irritability, confusion, slowed thinking), swelling hands/ankles/feet.
Get medical help right away if you have any very serious side effects, including: severe constipation, bloating/swelling/pain in the stomach/abdomen, black/bloody stools, vomit that looks like coffee grounds, inability to move your muscles (paralysis), seizures.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Kayexalate (Sodium Polystyrene)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Kayexalate FDA Prescribing Information: Side Effects
Kayexalate (sodium polystyrene) may cause some degree of gastric irritation. Anorexia, nausea, vomiting, and constipation may occur especially if high doses are given. Also, hypokalemia, hypocalcemia, hypomagnesemia and significant sodium retention, and their related clinical manifestations, may occur (see WARNINGS). Occasionally diarrhea develops. Large doses in elderly individuals may cause fecal impaction (see PRECAUTIONS). Rare instances of intestinal necrosis have been reported. Intestinal obstruction due to concretions of aluminum hydroxide, when used in combination with Kayexalate (sodium polystyrene) , has been reported.
The following events have been reported from worldwide post marketing experience:
- Fecal impaction following rectal administration, particularly in children;
- Gastrointestinal concretions (bezoars) following oral administration;
- Ischemic colitis, gastrointestinal tract ulceration or necrosis which could lead to intestinal perforation; and,
- Rare cases of acute bronchitis and/or broncho-pneumonia associated with inhalation of particles of polystyrene sulfonate.
Read the entire FDA prescribing information for Kayexalate (Sodium Polystyrene)
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