"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing of selexipag (Uptravi, Actelion Registration Ltd) for the treatment of adults with pulmonary arterial hypertension (PAH)./"...
(betaxolol hydrochloride and chlorthalidone) Tablets
Kerledex (betaxolol hydrochloride and chlorthalidone) is a combination product indicated for the treatment of hypertension. It combines the activities of betaxolol hydrochloride, a β1-selective (cardioselective) adrenergic receptor blocking agent, with chlorthalidone, a monosulfamyl diuretic.
Betaxolol hydrochloride is chemically described as 2-propanol, 1-[4-[2-(cyclopropylmethoxy) ethyl] phenoxy]-3-[(1-methylethyl)amino]-,hydrochloride,(±). It has the following chemical structure:
Betaxolol hydrochloride is a water-soluble white crystalline powder with a molecular formula of C18H29NO3 • HCl and a molecular weight of 343.9. It is freely soluble in water, ethanol, chloroform, and methanol, and has a pKa of 9.4.
Chlorthalidone, a monosulfamyl diuretic, differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. It is 2-chloro-5-(1-hydroxy-3-oxo-1isoindolinyl)benzenesulfonamide with a molecular formula of C14H11ClN2O4S and a molecular weight of 338.76. It is practically insoluble in water, ether and chloroform; soluble in methanol; and slightly soluble in alcohol.
Kerledex is available as orally administered tablets containing 5 or 10 mg of betaxolol HCl and 12.5 mg of chlorthalidone (5/12.5; 10/12.5). Inactive ingredients include corn starch, hydroxypropyl methylcellulose, iron oxide colorant, lactose, magnesium stearate, polyethylene glycol 400, povidone, and titanium dioxide.
Last reviewed on RxList: 1/11/2017
This monograph has been modified to include the generic and brand name in many instances.
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