"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing of selexipag (Uptravi, Actelion Registration Ltd) for the treatment of adults with pulmonary arterial hypertension (PAH)./"...
Patients, especially those with evidence of coronary artery insufficiency, should be warned against interruption or discontinuation of Kerledex therapy without the physician's advice.
Although cardiac failure rarely occurs in appropriately selected patients, patients being treated with beta-adrenergic blocking agents should be advised to consult a physician at the first sign or symptom of heart failure.
Patients should know how they react to this medicine before they operate automobiles and machinery or engage in other tasks requiring alertness. Patients should also be cautioned that taking alcohol can increase the chance of dizziness occurring. Patients should contact their physician if any difficulty in breathing occurs, and before surgery of any type. Patients should inform their physicians or dentists that they are taking Kerledex. Patients with diabetes should be warned that beta-blockers may mask tachycardia occurring with hypoglycemia.
Patients should inform their physicians if they have: 1) had an allergic reaction to chlorthalidone or other diuretics or have asthma; 2) kidney disease; 3) liver disease; 4) gout; 5) systemic lupus erythematosus; or 6) been taking other drugs such as cortisone, digitalis, lithium carbonate, or drugs for diabetes.
Patients should be cautioned to contact their physician if they experience any of the following symptoms of potassium loss: excess thirst, tiredness, weakness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, increased heart rate or pulse, extra beats or irregular heart rhythms.
Last reviewed on RxList: 9/6/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Kerledex Information
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