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No specific information is available regarding overdosage with Kerledex in humans. Treatment is symptomatic and supportive.
No specific information on emergency treatment of overdosage with betaxolol is available. The most common effects expected are bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia. In one acute overdosage of betaxolol, a 16-yearold female recovered fully after ingesting 460 mg.
The oral LD50 of the betaxolol/chlorthalidone combination, administered in a ratio of 1:1.25, is 440 to 450 mg/kg in the mouse and 410 to 490 mg/kg in the rat.
In the case of overdosage, treatment with Kerledex should be stopped and the patient carefully observed. Hemodialysis or peritoneal dialysis does not remove substantial amounts of betaxolol. In addition to gastric lavage, the following therapeutic measures are suggested if warranted:
Hypotension: In addition to the usual supportive measures (eg, fluid replacement), the use of sympathomimetic pressor drug therapy, such as dopamine, dobutamine, or norepinephrine may be required. In refractory cases of overdosage of other beta-blockers, the use of glucagon hydrochloride has been reported to be useful.
Bradycardia: Atropine should be administered. If there is no response to vagal blockade, isoproterenol should be administered cautiously. In refractory cases the use of a transvenous cardiac pacemaker may be considered.
Acute cardiac failure: Conventional therapy including digitalis, diuretics, and oxygen should be instituted immediately.
Bronchospasm: Use a β2-agonist. Additional therapy with aminophylline may be considered.
Heart block (2nd- or 3rd-Degree): Use isoproterenol or a transvenous cardiac pacemaker.
Electrolyte imbalance: Supportive treatment, with appropriate electrolyte therapy, should be instituted and monitored.
Kerledex is contraindicated in patients with anuria, sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure (see WARNINGS). It is also contraindicated in patients with a known hypersensitivity to any of the individual components or other sulfonamide-derived drugs.
Last reviewed on RxList: 9/6/2011
This monograph has been modified to include the generic and brand name in many instances.
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