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No specific information on emergency treatment of overdosage with Kerlone (betaxolol hydrochloride) is available. The most common effects expected are bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia. In one acute overdosage of betaxolol, a 16-year-old female recovered fully after ingesting 460 mg.
Oral LD50s are 350 to 400 mg betaxolol/kg in mice and 860 to 980 mg/kg in rats.
In the case of overdosage, treatment with Kerlone (betaxolol hydrochloride) should be stopped and the patient carefully observed. Hemodialysis or peritoneal dialysis does not remove substantial amounts of the drug. In addition to gastric lavage, the following therapeutic measures are suggested if warranted:
Hypotension: Use sympathomimetic pressor drug therapy, such as dopamine, dobutamine, or norepinephrine. In refractory cases of overdosage of other beta-blockers, the use of glucagon hydrochloride has been reported to be useful.
Bradycardia:Atropine should be administered. If there is no response to vagal blockade, isoproterenol should be administered cautiously. (see WARNINGS: Anesthesia and major surgery). In refractory cases the use of a transvenous cardiac pacemaker may be considered.
Acute cardiac failure: Conventional therapy including digitalis, diuretics, and oxygen should be instituted immediately.
Bronchospasm: Use a β2- agonist. Additional therapy with aminophylline may be considered.
Heart block (2nd- or 3rd-degree): Use isoproterenol or a transvenous cardiac pacemaker.
Kerlone (betaxolol hydrochloride) is contraindicated in patients with known hypersensitivity to the drug. Kerlone (betaxolol hydrochloride) is contraindicated in patients with sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. (see WARNINGS).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 7/28/2009
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