Ketek (Telithromycin) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Sinus Infection »

Sinus infection facts

Sinus infections are caused by infections from a pathogenic microorganism (virus, bacterium, or fungus), which grows within a sinus and causes intermittent blockage of the sinus ostium.
Most people do not transmit sinus infections; most clinicians agree that except for rare instances, sinus infections are not contagious but arise from mainly viruses and bacteria that, by chance, contaminate a person who sinuses support their proliferation because of minor, and rarely, major abnormalities in the person's sinus tissue (for example, swelling, inflammation, abnormal mucus production, and rarely, facial or nasal trauma).
Sinusitis is inflammation of the air cavities within the passages of the nose. Sinusitis can be caused by infection, but also can be caused by allergies and chemical or particulate irritation of the sinuses.
Sinusitis may be classified in several ways such as acute sinus infec...

Read the Sinus Infection article »

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OVERDOSE

In the event of acute overdosage, the stomach should be emptied by gastric lavage. The patient should be carefully monitored (e.g., ECG, electrolytes) and given symptomatic and supportive treatment. Adequate hydration should be maintained. The effectiveness of hemodialysis in an overdose situation with KETEK (telithromycin) is unknown.

CONTRAINDICATIONS

KETEK (telithromycin) is contraindicated in patients with myasthenia gravis. Exacerbations of myasthenia gravis have been reported in patients and sometimes occurred within a few hours of the first dose of telithromycin. Reports have included fatal and life-threatening acute respiratory failure with a rapid onset and progression.

KETEK (telithromycin) is contraindicated in patients with previous history of hepatitis and/or jaundice associated with the use of KETEK (telithromycin) tablets, or any macrolide antibiotic.

KETEK (telithromycin) is contraindicated in patients with a history of hypersensitivity to telithromycin and/or any components of KETEK (telithromycin) tablets, or any macrolide antibiotic.

Concomitant administration of KETEK (telithromycin) with cisapride or pimozide is contraindicated. (See CLINICAL PHARMACOLOGY, Drug-drug Interactions and PRECAUTIONS.)

Concomitant administration of KETEK (telithromycin) and colchicine is contraindicated in patients with renal or hepatic impairment. (See WARNINGS, DRUG INTERACTIONS and PRECAUTIONS: DRUG INTERACTIONS.)

Last reviewed on RxList: 1/27/2011
This monograph has been modified to include the generic and brand name in many instances.