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In the event of acute overdosage, the stomach should be emptied by gastric lavage. The patient should be carefully monitored (e.g., ECG, electrolytes) and given symptomatic and supportive treatment. Adequate hydration should be maintained. The effectiveness of hemodialysis in an overdose situation with KETEK is unknown.
KETEK is contraindicated in patients with myasthenia gravis. Exacerbations of myasthenia gravis have been reported in patients and sometimes occurred within a few hours of the first dose of KETEK. Reports have included fatal and life-threatening acute respiratory failure with a rapid onset and progression.
KETEK is contraindicated in patients with a history of hypersensitivity to telithromycin, any components of KETEK tablets, or any macrolide antibacterial.[see DESCRIPTION]
Concomitant administration of KETEK with cisapride or pimozide is contraindicated because coadministration can lead to life-threatening QT prolongation. [see WARNINGS AND PRECAUTIONS; DRUG INTERACTIONS]
Concomitant administration of KETEK and colchicine is contraindicated in patients with renal or hepatic impairment due to increased plasma concentration of colchicine leading to life-threatening colchicine toxicity. [see WARNINGS AND PRECAUTIONS; DRUG INTERACTIONS]This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 5/19/2016
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