Klaron

CLINICAL PHARMACOLOGY

The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, based on sulfonamides acting as a competitive inhibitor of para-aminobenzoic acid (PABA) utilization, an essential component for bacterial growth. While absorption through intact skin in humans has not been determined, in vitro studies with human cadaver skin indicated a percutaneous absorption of about 4%. Sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine largely unchanged. The biological half-life has been reported to be between 7 to 13 hours.

The pharmacokinetics of sulfacetamide and its major metabolite sulfaniliamide in Klaron (sodium sulfacetamide lotion) Lotion was evaluated in adult subjects (N=14) with acne vulgaris. The subjects applied Klaron (sodium sulfacetamide lotion) Lotion to their face, back, chest and shoulders every 12 hours for 28 days. The percentage of the applied dose of Klaron (sodium sulfacetamide lotion) Lotion excreted in the urine as sulfacetamide plus sulfanilamide, ranged from 0.08 to 0.33%.

Last reviewed on RxList: 7/28/2010
This monograph has been modified to include the generic and brand name in many instances.

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