"Miriam E. Tucker
Medscape Medical News
The US Food and Drug Administration has approved the empagliflozin/linagliptin combination Glyxambi (Boehringer Ingelheim/Eli Lilly) as adjunctive treatment to diet and "...
Kombiglyze XR Patient Information including If I Miss a Dose
In this Article
- What is metformin and saxagliptin (Kombiglyze XR)?
- What are the possible side effects of metformin and saxagliptin (Kombiglyze XR)?
- What is the most important information I should know about metformin and saxagliptin (Kombiglyze XR)?
- What should I discuss with my healthcare provider before taking metformin and saxagliptin (Kombiglyze XR)?
- How should I take metformin and saxagliptin (Kombiglyze XR)?
- What happens if I miss a dose (Kombiglyze XR)?
- What happens if I overdose (Kombiglyze XR)?
- What should I avoid while taking metformin and saxagliptin (Kombiglyze XR)?
- What other drugs will affect metformin and saxagliptin (Kombiglyze XR)?
- Where can I get more information?
What happens if I miss a dose (Kombiglyze XR)?
Take the missed dose as soon as you remember (be sure to take the medicine with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Kombiglyze XR)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
An overdose of metformin may cause lactic acidosis. Get emergency medical help if you have: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
What should I avoid while taking metformin and saxagliptin (Kombiglyze XR)?
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.
What other drugs will affect metformin and saxagliptin (Kombiglyze XR)?
Tell your doctor about all other medicines you use, especially:
- an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), telithromycin (Ketek), trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra), or vancomycin (Vancocin, Lyphocin);
- antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
- heart or blood pressure medication such as amiloride (Midamor), digoxin (Lanoxin), diltiazem (Cartia, Cardizem), furosemide (Lasix), nifedipine (Nifedical), procainamide (Procan, Pronestyl, Procanbid), quinidine (Quin-G), triamterene (Dyrenium), and others; or
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra).
You may be more likely to have hyperglycemia (high blood sugar) if you take metformin and saxagliptin with other drugs that can raise blood sugar, such as:
- diuretics (water pills);
- steroids (prednisone and others);
- niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
- phenothiazines (Compazine and others);
- thyroid medicine (Synthroid and others);
- birth control pills and other hormones;
- seizure medicines (Dilantin and others); or
- diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you take metformin and saxagliptin with other drugs that can lower blood sugar, such as:
- some nonsteroidal anti-inflammatory drugs (NSAIDs);
- aspirin or other salicylates (including Pepto-Bismol);
- a blood thinner (warfarin, Coumadin, Jantoven, and others);
- heart or blood pressure medication (Accupril, Altace, Lotensin, Prinivil, Vasotec, Zestril, and others);
- sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others);
- a monoamine oxidase inhibitor (MAOI); or
- insulin or another oral diabetes medication, such as acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Metaglip), glimepiride (Amaryl, Avandaryl, Duetact), glyburide (DiaBeta, Micronase, Glucovance), metformin (Glucophage), miglitol (Glyset), pioglitazone (Actos), rosiglitazone (Avandia), tolazamide (Tolinase), or tolbutamide (Orinase).
These lists are not complete and there are many other medicines that can increase or decrease the effects of metformin and saxagliptin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about metformin and saxagliptin.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Kombiglyze XR Information
- Kombiglyze XR Drug Interactions Center: saxagliptin-metformin oral
- Kombiglyze XR Side Effects Center
- Kombiglyze XR FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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