"Nov. 27, 2012 -- Countries that mix high-fructose corn syrup into processed foods and soft drinks have higher rates of diabetes than countries that don't use the sweetener, a new study shows.
In a study published in the journal Glo"...
- Clinician Information:
Kombiglyze XR Patient Information including How Should I Take
In this Article
- What is metformin and saxagliptin (Kombiglyze XR)?
- What are the possible side effects of metformin and saxagliptin (Kombiglyze XR)?
- What is the most important information I should know about metformin and saxagliptin (Kombiglyze XR)?
- What should I discuss with my healthcare provider before taking metformin and saxagliptin (Kombiglyze XR)?
- How should I take metformin and saxagliptin (Kombiglyze XR)?
- What happens if I miss a dose (Kombiglyze XR)?
- What happens if I overdose (Kombiglyze XR)?
- What should I avoid while taking metformin and saxagliptin (Kombiglyze XR)?
- What other drugs will affect metformin and saxagliptin (Kombiglyze XR)?
- Where can I get more information?
What should I discuss with my healthcare provider before taking metformin and saxagliptin (Kombiglyze XR)?
Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney disease, heart attack or congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol.
Do not use this medication if you are allergic to metformin (Actoplus Met, Avandamet, Fortamet, Glucophage, Riomet) or saxagliptin (Onglyza), if you have kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and saxagliptin. Be sure your caregivers know ahead of time that you are using this medication.
To make sure you can safely take metformin and saxagliptin, tell your doctor if you have any of these other conditions:
- liver disease;
- heart disease; or
- if you are over 80 years old;
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with metformin and saxagliptin.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether metformin and saxagliptin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medication to anyone under 18 years old without your doctor's advice.
How should I take metformin and saxagliptin (Kombiglyze XR)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
Take metformin and saxagliptin with a meal.
Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Ask your doctor how to adjust your metformin and saxagliptin dose if needed. Do not change your medication dose or schedule without your doctor's advice.
Metformin and saxagliptin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, and eye care. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture and heat.
Additional Kombiglyze XR Information
- Kombiglyze XR Drug Interactions Center: saxagliptin-metformin oral
- Kombiglyze XR Side Effects Center
- Kombiglyze XR FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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