Konyne (Factor IX Complex) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

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Konyne

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DRUG DESCRIPTION

Factor IX Complex, Konyne (factor ix complex) ® 80, heat-treated at 80°C for 72 hours, is a sterile, dried, plasma fraction comprising coagulation factors II, IX, X and low levels of factor VII.

Nomenclature

Factor: Synonyms:

II prothrombin

VII proconvertin

IX plasma thromboplastin component, PTC, Christmas factor

X Stuart-Prower factor

Konyne (factor ix complex) 80 is standardized in terms of factor IX content and each vial of Konyne (factor ix complex) 80 is labeled for factor IX. One international unit (IU) of factor IX as defined by the World Health Organization standard for blood coagulation factor IX is approximately equal to the level of factor IX found in 1.0 mL of fresh, normal plasma.

The factor IX content is approximately 50 times purified over whole plasma, and when reconstituted as directed, Konyne (factor ix complex) 80 contains 25 times as much factor IX as an equal volume of fresh plasma. Konyne 80, containing approximately 1000 IU of factor IX administered in 40 mL, contains the factor IX content of 1 liter of fresh plasma. Konyne (factor ix complex) 80 must be administered intravenously.

What are the possible side effects of factor IX complex?

Factor IX complex is made from human plasma (part of the blood) and may contain infectious agents (e.g., viruses) that can cause disease. Although factor IX complex is screened, tested, and treated to reduce the possibility that it carries an infectious agent, it can still potentially transmit disease. Discuss with your doctor the risks and benefits of using factor IX complex.

Some viruses, such as parovovirus B19 and hepatitis A, may be more difficult to identify or remove from factor IX complex. Parovovirus B19 may more seriously affect pregnant...

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What are the precautions when taking factor ix complex (Konyne)?

Before using factor IX, tell your doctor or pharmacist if you are allergic to factor IX products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other clotting disorders (e.g., disseminated intravascular coagulation-DIC), heart disease (e.g., coronary artery disease), immune system problems, recent surgery/procedure, liver disease.

Before having surgery, tell your doctor or dentist that you are using this medication.

Since this medication is made from human blood, there is a very small chance that you may get infections from it (e.g., viral...

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Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.