No reports of overdosage with KRYSTEXXA (pegloticase injection) have been reported. The maximum dose that has been administered as a single intravenous dose is 12 mg as uricase protein.
Patients suspected of receiving an overdose should be monitored, and general supportive measures should be initiated as no specific antidote has been identified.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency: KRYSTEXXA (pegloticase injection) is contraindicated in patients with G6PD deficiency due to the risk of hemolysis and methemoglobinemia. It is recommended that patients at higher risk for G6PD deficiency (e.g., patients of African or Mediterranean ancestry) be screened for G6PD deficiency before starting KRYSTEXXA (pegloticase injection) .
Last reviewed on RxList: 7/12/2012
This monograph has been modified to include the generic and brand name in many instances.
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