"An advisory committee to the US Food and Drug Administration (FDA) voted 10 to 4 to recommend lesinurad (Zurampic, AstraZeneca) 200 mg once daily for the treatment of gout-associated hyperuricemia, in combination with a xanthine oxidase "...
Krystexxa Patient Information including How Should I Take
In this Article
- What is pegloticase (Krystexxa)?
- What are the possible side effects of pegloticase (Krystexxa)?
- What is the most important information I should know about pegloticase (Krystexxa)?
- What should I discuss with my healthcare provider before taking pegloticase (Krystexxa)?
- How should I take pegloticase (Krystexxa)?
- What happens if I miss a dose (Krystexxa)?
- What happens if I overdose (Krystexxa)?
- What should I avoid while taking pegloticase (Krystexxa)?
- What other drugs will affect pegloticase (Krystexxa)?
- Where can I get more information?
What should I discuss with my healthcare provider before taking pegloticase (Krystexxa)?
You should not receive pegloticase if you are allergic to it, or if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Some drugs can interact with pegloticase and should not be used at the same time. Tell your doctor about all other medications you use, especially:
- allopurinol (Zyloprim);
- probenecid (Benemid); or
- febuxostat (Uloric).
To make sure pegloticase is safe for you, tell your doctor about your other medical conditions, especially:
- congestive heart failure;
- other heart problems; or
- high blood pressure.
FDA pregnancy category C. It is not known whether pegloticase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether pegloticase passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pegloticase.
How should I take pegloticase (Krystexxa)?
Pegloticase is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Pegloticase must be given slowly, and the IV infusion can take at least 2 hours to complete.
You may be given other medications to prevent certain side effects of pegloticase. You may need to start taking these medications at least a week before you receive your pegloticase injection. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
Pegloticase is usually given once every 2 weeks. Follow your doctor's dosing instructions very carefully.
When you first start using pegloticase, you may have an increase in gout flares. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 3 months of treatment.
Your doctor may recommend other gout medications during the first 6 months of your treatment with pegloticase.
To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with pegloticase. Visit your doctor regularly.
Additional Krystexxa Information
- Krystexxa Drug Interactions Center: pegloticase iv
- Krystexxa Side Effects Center
- Krystexxa Overview including Precautions
- Krystexxa FDA Approved Prescribing Information including Dosage
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