November 28, 2015
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"The U.S. Food and Drug Administration today approved Repatha (evolocumab) injection for some patients who are unable to get their low-density lipoprotein (LDL) cholesterol under control with current treatment options.

Repatha, the second dr"...




There have been no reports of overdose with KYNAMRO treatment. In clinical trials, patients receiving higher doses of KYNAMRO (300 mg and 400 mg once weekly for 13 weeks) experienced adverse reactions similar to the adverse reactions experienced by patients receiving treatment with 200 mg once weekly but at slightly higher rates and greater severity. Liver-related tests should be monitored. Although there is no information on the effect of hemodialysis in treating an overdose with mipomersen, hemodialysis is unlikely to be useful in overdose management since mipomersen is highly bound to plasma proteins.


KYNAMRO is contraindicated in the following conditions:

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 3/13/2015


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Cholesterol Management

Tips to keep it under control.