Kytril Injection (Granisetron Hydrochloride) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Kytril Injection

Nausea and Vomiting »

Nausea and vomiting facts

Nausea and vomiting are symptoms of a disease or condition. The underlying cause of the illness causing nausea and vomiting should be identified and treated.
Nausea and vomiting symptom control is important both for comfort's sake and to prevent dehydration.
Dehydration can worsen nausea and vomiting.
Medication may be available to control symptoms of nausea and vomiting.

Introduction to nausea and vomiting

Nausea and vomiting are symptoms of an underlying illness and not a specific disease. Nausea is the sensation that the stomach wants to empty itself, while vomiting (emesis) or throwing up, is the act of forcible emptying of the stomach. The term "dry heaves" refers to an episode of vomiting where there is no food in the stomach to vomit, and only clear secretions are vomited.

Vomiting is a violent act in which the stomach almost...

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PATIENT INFORMATION

Patients should be informed that the most common adverse reactions for the indication of chemotherapy induced nausea and vomiting are headache and constipation (see Table 1).

Patients should be informed that the most common adverse reactions for the indication of postoperative nausea and vomiting are pain, headache, fever, abdominal pain and hepatic enzyme increased (see Table 2).

Patients should be advised of the risk of allergic reactions if they have a prior allergic reaction to a class of antiemetics known as 5-HT₃ receptor antagonists.

Electrocardiogram changes (QT prolongation) have been reported with the use of KYTRIL. Patients should be cautioned about the use of this drug if they have heart problems or take medications for heart problems.

Patients should be informed that KYTRIL Injection (1 mg/mL) contains benzyl alcohol and may cause serious side effects in newborns. KYTRIL Injection 0.1 mg/mL contains no benzyl alcohol.

Last reviewed on RxList: 6/22/2011
This monograph has been modified to include the generic and brand name in many instances.