September 1, 2015

L-Arginine

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Are there any interactions with medications?



Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Major Do not take this combination.

L-arginine seems to decrease blood pressure. Taking L-arginine along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine seems to decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking L-arginine along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



Medications for high blood pressure (ACE inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine seems to decrease blood pressure. Taking L-arginine along with certain medications for high blood pressure, called ACE inhibitors might cause your blood pressure to go too low. Also, ACE inhibitors can increase potassium levels. L-arginine may also increase potassium levels. Taking L-arginine with ACE inhibitors might cause potassium levels to become to high.

Some ACE inhibitors include benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik).



Medications for high blood pressure (Angiotensin receptor blockers (ARBs))
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine seems to decrease blood pressure. Taking L-arginine along with medications for high blood pressure might cause your blood pressure to go too low.

The ARBs include losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), candesartan (Atacand), telmisartan (Micardis), and eprosartan (Teveten).



Medications for high blood pressure (Isoproterenol)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine seems to decrease blood pressure. Isoproterenol is a drug that is used to lower blood pressure. Taking L-arginine along with isoproterenol might cause your blood pressure to go too low.



Medications that increase blood flow to the heart (Nitrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine increases blood flow. Taking L-arginine with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness.

Some of these medications that increase blood flow to the heart include nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat), and isosorbide (Imdur, Isordil, Sorbitrate).



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine seems to slow blood clotting. Taking L-arginine along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.



Sildenafil (Viagra)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Sildenafil (Viagra) can lower blood pressure. L-arginine can also lower blood pressure. Taking sildenafil (Viagra) and L-arginine together might cause the blood pressure to go too low. Blood pressure that is too low can cause dizziness and other side effects.



Water pills (Potassium-sparing diuretics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

L-arginine might increase potassium levels in the body. Some "water pills" might also increase potassium in the body. In theory, taking L-arginine along with some "water pills" might cause too much potassium to be in the body. Some water pills include amiloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium).

Some "water pills" that increase potassium in the body include spironolactone (Aldactone), triamterene (Dyrenium), and amiloride (Midamor).

Dosing considerations for L-arginine.

The following doses have been studied in scientific research:

BY MOUTH:
  • For congestive heart failure: doses range from 6-20 grams per day, as three divided doses.
  • For chest pain associated with coronary artery disease (angina pectoris): 3-6 grams three times per day for up to one month.
  • For preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease (angina pectoris): 700 mg four times daily.
  • For organic erectile dysfunction (ED): 5 grams per day. Taking lower doses might not be effective.
  • For preventing inflammation of the digestive tract in premature infants: 261 mg/kg added to oral feedings daily for the first 28 days of life.

Therapeutic Research Faculty copyright

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