"The U.S. Food and Drug Administration today approved the Argus II Retinal Prosthesis System, the first implanted device to treat adult patients with advanced retinitis pigmentosa (RP). The device, which includes a small video camera, transmitter "...
(hydroxypropyl cellulose ophthalmic insert)
LACRISERT* (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.
The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is an ether of cellulose in which hydroxypropyl groups (-CH2CHOHCH3) are attached to the hydroxyls present in the anhydroglucose rings of cellulose by ether linkages. A representative structure of the monomer is:
The molecular weight is typically 1 x 106.
Hydroxypropyl cellulose is an off-white, odorless, tasteless powder. It is soluble in water below 38°C, and in many polar organic solvents such as ethanol, propylene glycol, dioxane, methanol, isopropyl alcohol (95%), dimethyl sulfoxide, and dimethyl formamide.
Each LACRISERT is 5 mg of hydroxypropyl cellulose. LACRISERT (cellulose) contains no preservatives or other ingredients. It is about 1.27 mm in diameter by about 3.5 mm long.
LACRISERT (cellulose) is supplied in packages of 60 units, together with illustrated instructions and a special applicator for removing LACRISERT (cellulose) from the unit dose blister and inserting it into the eye. A spare applicator is included in each package.
*Registered trademark of ATON PHARMA, INC. COPYRIGHT © ATON PHARMA, INC., 2007 All rights reserved
Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.
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