Lacrisert (Cellulose) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

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Sjogren's Syndrome »

Sjögren's syndrome facts

Sjögren's syndrome is an autoimmune disease.
Sjögren's syndrome involves inflammation of glands and other tissues of the body.
About 90% of Sjögren's syndrome patients are female.
Sjögren's syndrome can be complicated by infections of the eyes, breathing passages, and mouth.
Sjögren's syndrome is typically associated with antibodies against a variety of body tissues (autoantibodies).
Diagnosis of Sjögren's syndrome can be aided by a saliva-gland biopsy.
Treatment of patients with Sjögren's syndrome is directed toward the particular areas of the body that are involved and complications, such as infection.

What is Sjögren's syndrome?

Sjögren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. Autoimmune diseases feature the abnormal pr...

Read the Sjogren's Syndrome article »

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LACRISERT®
(hydroxypropyl cellulose ophthalmic insert)

DRUG DESCRIPTION

LACRISERT* (hydroxypropyl cellulose ophthalmic insert) is a sterile, translucent, rod-shaped, water soluble, ophthalmic insert made of hydroxypropyl cellulose, for administration into the inferior cul-de-sac of the eye.

The chemical name for hydroxypropyl cellulose is cellulose, 2-hydroxypropyl ether. It is an ether of cellulose in which hydroxypropyl groups (-CH₂CHOHCH₃) are attached to the hydroxyls present in the anhydroglucose rings of cellulose by ether linkages. A representative structure of the monomer is:

LACRISERT® (HYDROXYPROPYL CELLULOSE OPHTHALMIC INSERT) Structural Formula Illustration

The molecular weight is typically 1 x 106.

Hydroxypropyl cellulose is an off-white, odorless, tasteless powder. It is soluble in water below 38°C, and in many polar organic solvents such as ethanol, propylene glycol, dioxane, methanol, isopropyl alcohol (95%), dimethyl sulfoxide, and dimethyl formamide.

Each LACRISERT is 5 mg of hydroxypropyl cellulose. LACRISERT (cellulose) contains no preservatives or other ingredients. It is about 1.27 mm in diameter by about 3.5 mm long.

LACRISERT (cellulose) is supplied in packages of 60 units, together with illustrated instructions and a special applicator for removing LACRISERT (cellulose) from the unit dose blister and inserting it into the eye. A spare applicator is included in each package.

Last reviewed on RxList: 3/13/2008
This monograph has been modified to include the generic and brand name in many instances.