March 25, 2017
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Lactated Ringers

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Lactated Ringer's




Lactated Ringers Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/03/2016

Lactated Ringer's Injection is an electrolyte replenisher indicated as a source of water and electrolytes or as an alkalinizing agent. Lactated Ringer's Injection is available in generic form. Common side effects of Lactated Ringer's Injection include:

  • allergic reactions, such as localized or generalized hives and itching, swelling of the eyes, face, or throat, coughing, sneezing, or difficulty breathing.
  • Other side effects of Lactated Ringer's Injection may include fever,
  • infection at injection site, or
  • redness/red streaking and swelling from the site of injection.

The dose of Lactated Ringer's is as directed by a physician. Dosage is dependent upon the age, weight and clinical condition of the patient as well as laboratory determinations. Lactated Ringer's may interact with corticosteroids or corticotropin. Other drugs may affect Lactated Ringer's. Tell your doctor about all the prescription and over-the-counter medications and supplements you use. Lactated Ringer's Injection, USP should be given to a pregnant woman only if prescribed. It is not known whether this drug is passed in breast milk. Consult your doctor before breastfeeding.

Our Lactated Ringer's Injection, USP Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Lactated Ringers FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

Too rapid infusion of hypertonic solutions may cause local pain and venous irritation. Rate of administration should be adjusted according to tolerance. Use of the largest peripheral vein and a small bore needle is recommended. (See DOSAGE AND ADMINISTRATION.)

Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential.

Hypernatremia may be associated with edema and exacerbation of congestive heart failure due to the retention of water, resulting in an expanded extracellular fluid volume.

Reactions reported with the use of potassium-containing solutions include nausea, vomiting, abdominal pain and diarrhea. The signs and symptoms of potassium intoxication include paresthesias of the extremities, areflexia, muscular or respiratory paralysis, mental confusion, weakness, hypotension, cardiac arrhythmias, heart block, electrocardiographic abnormalities and cardiac arrest. Potassium deficits result in disruption of neuromuscular function, and intestinal ileus and dilatation.

If infused in large amounts, chloride ions may cause a loss of bicarbonate ions, resulting in an acidifying effect.

Abnormally high plasma levels of calcium can result in depression, amnesia, headaches, drowsiness, disorientation, syncope, hallucinations, hypotonia of both skeletal and smooth muscles, dysphagia, arrhythmias and coma. Calcium deficits can result in neuromuscular hyperexcitability, including cramps and convulsions.

Although the metabolism of lactate to bicarbonate is a relatively slow process, aggressive administration of sodium lactate may result in metabolic alkalosis. Careful monitoring of blood acidbase balance is essential during the administration of sodium lactate.

The physician should also be alert to the possibility of adverse reactions to drug additives. Prescribing information for drug additives to be administered in this manner should be consulted.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

Other manifestations of hypersensitivity/infusion reactions: decreased heart rate, tachycardia, blood pressure decreased, respiratory distress, laryngeal edema, flushing, throat irritation, paresthesias, hypoesthesia oral, dysgeusia, anxiety, headache, and sneezing.

Hyperkalemia

Hypervolemia

Other infusion site reactions: infection at the site of injection, phlebitis, extravasation, infusion site inflammation, infusion site swelling, infusion site rash, infusion site pain, infusion site burning.

Read the entire FDA prescribing information for Lactated Ringers (Lactated Ringer's Injection)

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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