"Hospitals in the U.S. continue to make progress in the fight against central line-associated bloodstream infections and some surgical site infections, according to a report issued today by the Centers for Disease Control and Prevention (CDC). "...
Lamprene (clofazimine) exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus). Lamprene (clofazimine) inhibits mycobacterial growth and binds preferentially to mycobacterial DNA. Lamprene (clofazimine) also exerts anti-inflammatory properties in controlling erythema nodosum leprosum reactions. However, its precise mechanisms of action are unknown.
Lamprene (clofazimine) has a variable absorption rate in leprosy patients, ranging from 45%-62% after oral administration. The average serum concentrations in leprosy patients treated with 100 mg and 300 mg daily were 0.7 µg/mL and 1.0 µg/mL, respectively. After ingestion of a single dose of 300 mg, elimination of unchanged Lamprene (clofazimine) and its metabolites in a 24-hour urine collection was negligible. Lamprene (clofazimine) is retained in the human body for a long time. The half-life of Lamprene (clofazimine) following repeated oral doses is estimated to be at least 70 days. Part of the ingested drug recovered from the feces may represent excretion via the bile. A small amount is also eliminated in the sputum, sebum, and sweat.
Lamprene (clofazimine) is highly lipophilic and tends to be deposited predominantly in fatty tissue and in cells of the reticuloendothelial system. It is taken up by macrophages throughout the body. In autopsies performed on leprosy patients, clofazimine crystals were found predominantly in the mesenteric lymph nodes, adrenals, subcutaneous fat, liver, bile, gall bladder, spleen, small intestine, muscles, bones, and skin.
Measurement of the minimum inhibitory concentration (MIC) of Lamprene (clofazimine) against leprosy bacilli in vitro is not yet feasible. In the mouse footpad system, the multiplication of M. leprae is inhibited by introducing 0.0001%- 0.001% Lamprene (clofazimine) in the diet. Although bacterial killing may begin shortly after starting the drug, it cannot be measured in biopsy tissues taken from patients for mouse footpad studies until approximately 50 days after the start of therapy.
Lamprene (clofazimine) does not show cross-resistance with dapsone or rifampin.
The following in vitro data are available, but their clinical significance is unknown. Lamprene (clofazimine) has been shown in vitro to inhibit M. avium and M. bovis at concentrations of approximately 0.1-1.0 µg/mL. The MIC for M. avium-intracellulare isolated from patients with acquired immunodeficiency syndrome (AIDS) ranged from 1.0 to 5.0 µg/mL. With a few exceptions, microorganisms other than mycobacteria are not inhibited by Lamprene (clofazimine) .
Last reviewed on RxList: 11/5/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Lamprene Information
- Lamprene Drug Interactions Center: clofazimine oral
- Lamprene Side Effects Center
- Lamprene FDA Approved Prescribing Information including Dosage
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