October 5, 2015
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Side Effects


In general, Lamprene (clofazimine) is well tolerated when administered in dosages no greater than 100 mg daily. The most consistent adverse reactions are usually dose related and are usually reversible when Lamprene (clofazimine) is discontinued.

Adverse Reactions Occurring In More Than 1% of Patients

Skin: Pigmentation from pink to brownish-black in 75%-100% of the patients within a few weeks of treatment; ichthyosis and dryness (8%-28%); rash and pruritus (1%-5%).

Gastrointestinal: Abdominal and epigastric pain, diarrhea, nausea, vomiting, gastrointestinal intolerance (40%-50%).

Ocular: Conjunctival and corneal pigmentation due to clofazimine crystal deposits; dryness; burning; itching; irritation.

Other: Discoloration of urine, feces, sputum, sweat; elevated blood sugar; elevated ESR.

Adverse Reactions Occurring In Less Than 1% of Patients

Skin:Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis.

Gastrointestinal:Bowel obstruction (see WARNINGS), gastrointestinal bleeding (see WARNINGS), anorexia, constipation, weight loss, hepatitis, jaundice, eosinophilic enteritis, enlarged liver.

Ocular: Diminished vision.

Nervous: Dizziness, drowsiness, fatigue, headache, giddiness, neuralgia, taste disorder.

Psychiatric:Depression secondary to skin discoloration; two suicides have been reported.

Laboratory: Elevated levels of albumin, serum bilirubin, and AST (SGOT); eosinophilia; hypokalemia.

Other:Splenic infarction (see WARNINGS), thromboembolism, anemia, cystitis, bone pain, edema, fever, lymphadenopathy, vascular pain.

Read the Lamprene (clofazimine) Side Effects Center for a complete guide to possible side effects


Preliminary data which suggest that dapsone may inhibit the anti-inflammatory activity of Lamprene (clofazimine) have not been confirmed. If leprosy-associated inflammatory reactions develop in patients being treated with dapsone and clofazimine, it is still advisable to continue treatment with both drugs.

Read the Lamprene Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 11/5/2008
This monograph has been modified to include the generic and brand name in many instances.

Side Effects

Additional Lamprene Information

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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