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Lamprene

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Lamprene

Lamprene Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Lamprene (clofazimine) Soft Gelatin Capsules is an anti-leprosy drug used to treat lepromatous leprosy. Common side effects of Lamprene include changes in skin color, rash, itching, diarrhea, nausea, vomiting, eye irritation, and sweating.

The recommended dosage of Lamprene is 100 mg daily. Lamprene may interact with other drugs. Tell your doctor all medications you use. Before taking Lamprene tell your doctor if you have abdominal pain, diarrhea or other stomach problems. If you are pregnant only take Lamprene if the potential benefit outweighs the potential risk to the fetus. If you are breastfeeding only take Lamprene if clearly needed.

Our Lamprene (clofazimine) Soft Gelatin Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Lamprene FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

In general, Lamprene (clofazimine) is well tolerated when administered in dosages no greater than 100 mg daily. The most consistent adverse reactions are usually dose related and are usually reversible when Lamprene (clofazimine) is discontinued.

Adverse Reactions Occurring In More Than 1% of Patients

Skin: Pigmentation from pink to brownish-black in 75%-100% of the patients within a few weeks of treatment; ichthyosis and dryness (8%-28%); rash and pruritus (1%-5%).

Gastrointestinal: Abdominal and epigastric pain, diarrhea, nausea, vomiting, gastrointestinal intolerance (40%-50%).

Ocular: Conjunctival and corneal pigmentation due to clofazimine crystal deposits; dryness; burning; itching; irritation.

Other: Discoloration of urine, feces, sputum, sweat; elevated blood sugar; elevated ESR.

Adverse Reactions Occurring In Less Than 1% of Patients

Skin:Phototoxicity, erythroderma, acneiform eruptions, monilial cheilosis.

Gastrointestinal:Bowel obstruction (see WARNINGS), gastrointestinal bleeding (see WARNINGS), anorexia, constipation, weight loss, hepatitis, jaundice, eosinophilic enteritis, enlarged liver.

Ocular: Diminished vision.

Nervous: Dizziness, drowsiness, fatigue, headache, giddiness, neuralgia, taste disorder.

Psychiatric:Depression secondary to skin discoloration; two suicides have been reported.

Laboratory: Elevated levels of albumin, serum bilirubin, and AST (SGOT); eosinophilia; hypokalemia.

Other:Splenic infarction (see WARNINGS), thromboembolism, anemia, cystitis, bone pain, edema, fever, lymphadenopathy, vascular pain.

Read the entire FDA prescribing information for Lamprene (Clofazimine) »

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Additional Lamprene Information

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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