"The U.S. Food and Drug Administration today approved Entresto (sacubitril/valsartan) tablets for the treatment of heart failure. The drug has been shown to reduce the rate of cardiovascular death and hospitalization related to heart failure."...
Lanoxin Tablets Side Effects Center
Medical Editor: Charles Patrick Davis, MD, PhD
Lanoxin Tablets (digoxin) is a cardiac glycoside that has specific effects on the myocardial (heart muscle) tissue and is used to treat heart failure by increasing left ventricular ejection fractions and arrhythmias such as atrial fibrillation by controlling the ventricular response rate. Lanoxin is available in a generic form termed digoxin. Most side effects and toxicity of Lanoxin Tablets are avoided if the maintenance dose (see below) is within prescribed limits. Side effects of Lanoxin include nausea, vomiting, diarrhea, loss of appetite, weakness, dizziness, headache, anxiety, depression, slow heart rate (bradycardia), enlarged breasts in men, or skin rash.
Lanoxin Tablets are supplied as 125 or 250 mcg (microgram) once a day; adequate dosing without toxicity is determined usually by a blood test that determines the drug's level in the blood. Side effects and toxic effects of Lanoxin Tablets differ mainly in severity; symptoms are blurry or yellowish vision, anorexia, nausea, vomiting, and mental changes. More serious events such as cardiac PR interval prolongation, ST depression, heart block, ventricular tachycardia or ventricular fibrillation may occur. In children, sometimes the initial symptoms are cardiac arrhythmias such as bradycardia or tachycardias. There are no controlled studies of Lanoxin Tablets in pregnancy, although there are a few reports of its successful use. A few studies suggest only a small amount of Lanoxin reaches breast milk; currently, most investigators suggest that the benefits of drug use should outweigh the potential problems before Lanoxin is used in pregnant or lactating females.
Our Lanoxin Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Lanoxin Tablets in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fast, slow, or uneven heart rate;
- bloody or black, tarry stools;
- blurred vision, yellowed vision; or
- confusion, hallucinations, unusual thoughts or behavior.
Less serious side effects may include:
- nausea, vomiting, diarrhea, loss of appetite;
- feeling weak or dizzy;
- headache, anxiety, depression;
- enlarged breasts in men; or
- mild skin rash.
Read the entire detailed patient monograph for Lanoxin Tablets (Digoxin Tablets)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Lanoxin Tablets Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: weakness, mental/mood changes, vision changes (such as blurred or yellow/green vision), enlarged/tender breasts in men.
Though this medication is used to treat a certain type of irregular heartbeat, it may infrequently cause other types of irregular heartbeats. Tell your doctor immediately if you notice any unusually fast/slow/irregular heartbeat.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Lanoxin Tablets (Digoxin Tablets)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Lanoxin Tablets FDA Prescribing Information: Side Effects
The following adverse reactions are included in more detail in the WARNINGS AND PRECAUTIONS section of the label:
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
In general, the adverse reactions of LANOXIN are dose-dependent and occur at doses higher than those needed to achieve a therapeutic effect. Hence, adverse reactions are less common when LANOXIN is used within the recommended dose range, is maintained within the therapeutic serum concentration range, and when there is careful attention to concurrent medications and conditions.
In the DIG trial (a trial investigating the effect of digoxin on mortality and morbidity in patients with heart failure), the incidence of hospitalization for suspected digoxin toxicity was 2% in patients taking LANOXIN compared to 0.9% in patients taking placebo [see Clinical Studies].
The overall incidence of adverse reactions with digoxin has been reported as 5 to 20%, with 15 to 20% of adverse events considered serious. Cardiac toxicity accounts for about one-half, gastrointestinal disturbances for about one-fourth, and CNS and other toxicity for about one-fourth of these adverse events.
Gastrointestinal: In addition to nausea and vomiting, the use of digoxin has been associated with abdominal pain, intestinal ischemia, and hemorrhagic necrosis of the intestines.
Read the entire FDA prescribing information for Lanoxin Tablets (Digoxin Tablets)
Additional Lanoxin Information
Lanoxin Injection - User Reviews
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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