Brand Names: Latuda

Generic Name: lurasidone (Pronunciation: loo RAS i done)

• What is lurasidone (Latuda)?
• What are the possible side effects of lurasidone (Latuda)?
• What is the most important information I should know about lurasidone (Latuda)?
• What should I discuss with my healthcare provider before taking lurasidone (Latuda)?
• How should I take lurasidone (Latuda)?
• What happens if I miss a dose (Latuda)?
• What happens if I overdose (Latuda)?
• What should I avoid while taking lurasidone (Latuda)?
• What other drugs will affect lurasidone (Latuda)?
• Where can I get more information?

What is lurasidone (Latuda)?

Lurasidone is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Lurasidone is used to treat schizophrenia in adults.

Lurasidone may also be used for purposes not listed in this medication guide.

What are the possible side effects of lurasidone (Latuda)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking lurasidone and call your doctor at once if you have a serious side effect such as:

• dizziness, fainting, fast or pounding heartbeats;
• agitation, hostility, confusion, thoughts about hurting yourself;
• seizure (convulsions);
• fever, chills, body aches, flu symptoms, sores in your mouth and throat;
• high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);
• very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
• trouble swallowing; or
• twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Less serious side effects may include:

• drowsiness;
• feeling restless;
• nausea, diarrhea, stomach pain, loss of appetite;
• blurred vision;
• weight gain;
• breast swelling or discharge;
• missed menstrual periods; or
• decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Latuda (lurasidone hcl tablets for oral administration) Side Effects Center for a complete guide to possible side effects »

What is the most important information I should know about lurasidone (Latuda)?

Lurasidone is not for use in psychotic conditions related to dementia. Lurasidone may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use this medication if you are allergic to lurasidone, or if you are also using ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or rifampin (Rifater, Rifadin, Rifamate).

Before you take lurasidone, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or suicidal thoughts.

While you are taking lurasidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking lurasidone.

Lurasidone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Drinking alcohol can increase certain side effects of lurasidone.

Stop using lurasidone and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or pounding heartbeats, feeling like you might pass out, tremors, or twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

There are many other drugs that can interact with lurasidone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.