August 24, 2016
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Lazanda Patient Information Including Side Effects

Brand Names: Lazanda

Generic Name: fentanyl (nasal) (Pronunciation: FEN tan il)

What is fentanyl nasal (Lazanda)?

Fentanyl is an opioid pain medication. An opioid is sometimes called a narcotic.

Fentanyl nasal (for the nose) is used to treat "breakthrough" cancer pain. Lazanda is taken together with other non-fentanyl narcotic pain medicine that is used around the clock. This medication is not for treating pain that is not cancer-related, such as pain from surgery, dental work, or migraine headaches.

Fentanyl nasal is available only under a special program called Lazanda REMS. You must be registered in the program and sign documents stating that you understand the risks and benefits of using this medication.

Fentanyl nasal may also be used for purposes not listed in this medication guide.

What are the possible side effects of fentanyl nasal (Lazanda)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using fentanyl and call your doctor at once if you have a serious side effect such as:

  • slow heart rate, weak or shallow breathing, sighing;
  • confusion, extreme fear, unusual thoughts or behavior; or
  • feeling like you might pass out.

Less serious side effects may include:

  • nausea, vomiting, constipation;
  • dizziness, drowsiness, tired feeling; or
  • white patches or sores inside your mouth or on your lips.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Lazanda (fentanyl nasal spray) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about fentanyl nasal (Lazanda)?

Do not use Lazanda to replace any other form of fentanyl, such as Abstral, Actiq, Fentora, Onsolis, Duragesic, or generic brands of fentanyl (injection, skin patch, dissolving film, or "lollipop" device).

Tell your doctor if there are children living in the home where you will store this medicine. Keep this medicine out of the reach of children. The amount of fentanyl in each bottle of Lazanda can be fatal to a child.

Never share fentanyl with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

There are many other drugs that can interact with fentanyl. Tell your doctor about all medications you use.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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